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2 results on '"Jan Terock"'

1. Childhood Trauma and Functional Variants of 5-HTTLPR Are Independently Associated with Alexithymia in 5,283 Subjects from the General Population

Author

Harald J. Freyberger, Deborah Janowitz, Hans J. Grabe, Carsten Oliver Schmidt, Jan Terock, Sandra Van der Auwera, Anke Hannemann, Henriette E. Meyer zu Schwabedissen, and Georg Homuth

Subjects
Male, epidemiology [Affective Symptoms], Population, Polymorphism, Single Nucleotide, 03 medical and health sciences, 0302 clinical medicine, Alexithymia, Surveys and Questionnaires, genetics [Serotonin Plasma Membrane Transport Proteins], Medicine, Humans, Affective Symptoms, ddc:610, statistics & numerical data [Adult Survivors of Child Adverse Events], education, Applied Psychology, Serotonin Plasma Membrane Transport Proteins, education.field_of_study, business.industry, genetics [Affective Symptoms], SLC6A4 protein, human, General Medicine, Middle Aged, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Clinical Psychology, Adult Survivors of Child Adverse Events, 5-HTTLPR, genetics [Polymorphism, Single Nucleotide], Female, Self Report, business, 030217 neurology & neurosurgery, Clinical psychology
Published
2018

2. Association of Brain-Derived Neurotrophic Factor and Vitamin D with Depression and Obesity: A Population-Based Study

Author

Annemarie Goltz, Johanna Hoffmann, Hans J. Grabe, Tom Seyfart, Henry Völzke, Anke Hannemann, Deborah Janowitz, Jan Terock, and Matthias Nauck

Subjects
0301 basic medicine, medicine.medical_specialty, Population, Logistic regression, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Vitamin D and neurology, ddc:610, education, Biological Psychiatry, Abdominal obesity, Brain-derived neurotrophic factor, education.field_of_study, business.industry, medicine.disease, Obesity, Psychiatry and Mental health, 030104 developmental biology, Neuropsychology and Physiological Psychology, Endocrinology, Study of Health in Pomerania, medicine.symptom, business, Body mass index, 030217 neurology & neurosurgery
Abstract

Background: Depression and obesity are widespread and closely linked. Brain-derived neurotrophic factor (BDNF) and vitamin D are both assumed to be associated with depression and obesity. Little is known about the interplay between vitamin D and BDNF. We explored the putative associations and interactions between serum BDNF and vitamin D levels with depressive symptoms and abdominal obesity in a large population-based cohort. Methods: Data were obtained from the population-based Study of Health in Pomerania (SHIP)-Trend (n = 3,926). The associations of serum BDNF and vitamin D levels with depressive symptoms (measured using the Patient Health Questionnaire) were assessed with binary and multinomial logistic regression models. The associations of serum BDNF and vitamin D levels with obesity (measured by the waist-to-hip ratio [WHR]) were assessed with binary logistic and linear regression models with restricted cubic splines. Results: Logistic regression models revealed inverse associations of vitamin D with depression (OR = 0.966; 95% CI 0.951–0.981) and obesity (OR = 0.976; 95% CI 0.967–0.985). No linear association of serum BDNF with depression or obesity was found. However, linear regression models revealed a U-shaped association of BDNF with WHR (p < 0.001). Conclusion: Vitamin D was inversely associated with depression and obesity. BDNF was associated with abdominal obesity, but not with depression. At the population level, our results support the relevant roles of vitamin D and BDNF in mental and physical health-related outcomes.

Published
2017

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