1. Stiff-person syndrome first manifesting in pregnancy.
- Author
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Cerimagic D and Bilic E
- Subjects
- Adult, Autoantibodies analysis, Autoimmune Diseases diagnosis, Cesarean Section, Electromyography methods, Female, Follow-Up Studies, Glutamate Decarboxylase metabolism, Humans, Pregnancy, Pregnancy Complications immunology, Pregnancy Complications surgery, Pregnancy Trimester, Third, Rare Diseases, Risk Assessment, Stiff-Person Syndrome surgery, gamma-Aminobutyric Acid deficiency, Glutamate Decarboxylase immunology, Pregnancy Complications diagnosis, Pregnancy Outcome, Stiff-Person Syndrome diagnosis, Stiff-Person Syndrome immunology
- Abstract
Stiff-person syndrome (SPS) is a rare neurological disorder characterised by progressive stiffness and painful muscle spasms. We present a case of the autoimmune form of glutamate decarboxylase-positive SPS that initially manifested in pregnancy. The diagnosis was made based on clinical, laboratory and electromyoneurographic criteria. The patient was administered low doses of diazepam and baclofen. Considering the clinical picture of SPS patients, caesarean section is the method of choice for pregnancy termination. more...
- Published
- 2009
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