1. The mechanisms of peroxynitrite-induced relaxations in isolated rat anococcygeus muscle.
- Author
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Ademoğlu F, Başgut B, Abacioğlu N, and Cakici I
- Subjects
- Animals, Glyburide pharmacology, Guanylate Cyclase antagonists & inhibitors, In Vitro Techniques, Male, Muscle Relaxation drug effects, Muscle, Smooth physiology, Oxadiazoles pharmacology, Potassium Channel Blockers pharmacology, Quinoxalines pharmacology, Rats, Antioxidants pharmacology, Muscle, Smooth drug effects, Peroxynitrous Acid pharmacology
- Abstract
We have previously reported that peroxynitrite (ONOO(-)) caused relaxations on isolated rat anococcygeus muscle and in the present study the possible mechanisms of the relaxant effect were investigated. ONOO(-) (0.03- 1.0 mmol/l)-induced relaxations were reduced significantly by the presence of an ATP-sensitive potassium channel (K(+)(ATP) channel) blocker, glibenclamide (0.3 micromol/l), or 1H-(1,2,4)oxadiazolo(4,3-alpha)quinoxalin-1-one (ODQ) (30.0 micromol/l), a guanylyl cyclase inhibitor. However, 3-aminobenzamide (3.0 mmol/l), an inhibitor of poly(ADP- ribose)synthase, did not influence the relaxant effect of ONOO(-) (1.0 mmol/l). Results of the present study implicate that activation of K(+)(ATP) channels and/or cGMP/K(+)(ATP) channel interaction might play a role in the relaxant responses to ONOO(-) in isolated rat anococcygeus muscle., (Copyright 2002 S. Karger AG, Basel)
- Published
- 2002
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