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Background: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is the diagnostic tool of choice for pancreatic solid mass lesions. Pancreatic lymphomas represent an infrequent and challenging cytologic diagnosis. Our aim was to determine the diagnostic value of cellblock (CB) in the diagnosis of pancreatic lymphomas., Methods: We retrieved pancreatic EUS-FNAs performed over 10-years from our institution's database. We correlated the cytologic and CB diagnosis with the histologic diagnosis as a gold standard., Results: We found 5 cases (2 women and 3 men; age range, 37-66 years [average age, 52 years]) of pancreatic lymphomas with histologic follow-up biopsies. They included 1 case of T-cell lymphoma (TCL), 1 case of plasma cell neoplasm (multiple myeloma [MM]), 1 case of diffuse large B-cell lymphoma (DLBCL), 1 case of classic Hodgkin lymphoma (HL), and 1 case of high-grade B-cell lymphoma (HGBCL). Cytologically, the cases of HL and DLBCL were suspected, the cases of TCL and MM were confused with undifferentiated carcinoma and neuroendocrine carcinoma, and the case of HGBCL was inconclusive. CB samples were of value in highlighting the morphologic details of lymphomas and allowed confirmation, proper classification, and grading of the lymphomas using immunohistochemistry that matched tissue biopsies., Conclusions: EUS-FNA smears with CBs are helpful diagnostic tools, differentiating lymphomas from other malignancies and from nonneoplastic lymphocyte-rich lesions. CBs allow proper classification and grading of cases of pancreatic lymphomas., (© 2020 S. Karger AG, Basel.)

Objectives: Evidence-based medicine (EBM) relies on systematic review (SR), meta-analysis (MA) and randomized controlled trials (RCTs). These EBM tools are more commonly used in clinical medicine than in laboratory medicine. The extent of their use in cytopathology is not clear. The purpose of this study was to investigate the frequency of SR, MA and RCTs in cytopathology compared to other laboratory and clinical medicine specialties., Study Design: A literature-based search for SRs, MAs and RCTs in cytopathology was performed. Several electronic databases were searched without date restrictions. Four journals in cytopathology, pathology and clinical medicine were also searched over 6 years., Results: Gynecology cytology utilized SRs, MAs and RCTs more frequently (83%) than nongynecology and fine needle aspiration cytology. Cytopathology, histopathology and laboratory medicine journals showed comparable rates of 0.5-1.1% in papers reporting SRs, MAs and RCTs. Specialty medical journals showed a higher rate of 5.6% and general medical journals showed a much higher rate of 30%., Conclusions: SR, MA and RCTs are less frequently utilized in pathology than in clinical medicine. Cytopathologists should be more aware of the benefits of SR and MA in resolving uncertainties and improving the clinical applicability of level III diagnostic studies., (Copyright © 2012 S. Karger AG, Basel.)

Background: Posttransplant lymphoproliferative disorder (PTLPD) is a relatively common complication in kidney transplant recipients. It can involve the kidney allograft itself as well as extragraft sites. It is usually suspected clinically and diagnosed by tissue biopsy. It comprises a spectrum of lesions ranging from lymphoid byperplasia to frank lymphoma., Case: A 21-year-old male presented with recurrent episodes of microhematuria 2 years after a renal transplant. Voided urine cytology showed anaplastic, discohesive cells. Immunocytochemistry study on a urine cytospin showed the cells to be positive for LCA, CD20 and for CD79a and negative for CD3, CD15, CD30, cytokeratin, S-100 and HMB45, confirming their lymphoid origin., Conclusion: This is a rare suspected occurrence of PTLPD in voided urine. The presumptive diagnosis was supported by immunocytochemistry. However, voided urine cytology should not be considered a standard diagnostic test due to its low sensitivity. Diagnosis and proper subclassification of kidney PTLPD should be confirmed by histologic tissue study with supportive ancillary studies--e.g., immunohistochemistry and flow cytometry.

Objective: To report the first operated and histopathologically studied case of spontaneously resolving solitary osteochondroma., Case Presentation and Identification: An 18-year-old girl presented with leg pain of 2 months' duration. She had been diagnosed to have a proximal tibial osteochondroma since the age of 9 years. Excision biopsy of the tumor remnant and its surrounding tissue was done after CT and MRI imaging., Conclusion: The spontaneous resolution of this case could have been due to simultaneous interruption of blood supply to the tumor and its cartilaginous cap or hyperemia around the tumor., (Copyright (c) 2010 S. Karger AG, Basel.)

Objective: To investigate the potential significance of atypical bare nuclei in ThinPrep (TP) technique (Cytyc Corp., Boxborough, Massachusetts, U.S.A.), liquid-based cervical cytology and their possible association with certain epithelial abnormalities., Study Design: Four thousand seven hundred thirty-six TP cervical smears were reviewed over a period of 13 months. Cases in which atypical bare nuclei were detected were selected and were further studied for the clinical, cytomorphologic and histologic features associated with each case. Cases with "typical" bland-looking, free nuclei were excluded., Results: Ten cases were found to have atypical bare nuclei in the reviewed TP cervical smears. Nine were found to be associated with high grade squamous intraepithelial lesions (HSILs) and 6 were nonkeratinizing-type HSIL, 5 of which had endocervical involvement. None were associated with low grade squamous intraepithelial lesions (LSILs). One was associated with endometrial serous papillary carcinoma., Conclusion: In this study we tried to illustrate the significance of atypical bare nuclei in TP cervical smears. An association of atypical bare nuclei with HSIL, but not with LSIL, was observed. Attempts were made to explain this association and to suggest the potential management implications for TP cervical smears with such atypical bare nuclei.