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5. Interleukin-6 level is an independent predictor of right ventricular systolic dysfunction in patients hospitalized with COVID-19

Author

Selcuk Ozturk, Mehmet Erdoğan, Yunus Emre Özbebek, Mehmet Akif Erdöl, Rahmet Guner, Ayse Kaya Kalem, and Bircan Kayaaslan

Subjects
medicine.medical_specialty, biology, medicine.diagnostic_test, business.industry, Interleukin, Odds ratio, Doppler echocardiography, Doppler imaging, Confidence interval, Pathogenesis, Internal medicine, RC666-701, biology.protein, Cardiology, medicine, Diseases of the circulatory (Cardiovascular) system, Interleukin 6, Prospective cohort study, business, Original Investigation
Abstract

OBJECTIVE: Cytokine storm with elevated levels of multiple proinflammatory cytokines and inflammatory system activation underlie the pathogenesis of coronavirus disease 2019 (COVID-19). In this study, we aimed to investigate whether increased interleukin (IL)-6 levels can predict right ventricular (RV) systolic impairment in patients hospitalized with COVID-19. METHODS: This prospective, observational study included 100 consecutive patients hospitalized with mild and moderate COVID-19. All the patients underwent chest computerized tomography, detailed laboratory tests including IL-6, and two dimensional (2D) transthoracic echocardiography (TTE) with assessment of 2D conventional and Doppler echocardiography parameters and RV systolic functions. RESULTS: After the elimination of six patients with exclusion criteria, the remaining patients were classified into two groups, namely normal RV systolic functions (n=60) and impaired RV systolic functions (n=34). IL-6 levels were significantly higher in patients with impaired RV systolic functions than in those with normal RV systolic functions (20.3, 4.6, p

Published
2021

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