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Objective: To investigate the changes in otoacoustic emissions (OAEs) for detecting the ototoxicity of cisplatin and to study the possible preventive effect of N-acetylcysteine (NAC) in cisplatin ototoxicity. Materials and Methods: This study was conducted on 21 Wistar albino rats in four groups. Cisplatin, cisplatin plus NAC, NAC alone, and saline were intraperitoneally administered. The rats were anesthetized to study the otoacoustic emissions before and after the experiment. Results: The OAEs were attenuated in the cisplatin group: (-1.31/-4.90), (6.28/4.58), (4.00/0.93), (2.73/-3.74), (2.66/-4.53). The group that received NAC in addition to cisplatin had better OAEs. Conclusion: Cisplatin ototoxicity can be detected by OAE testing in rats, and NAC may reduce the ototoxic effect. [ABSTRACT FROM AUTHOR]

Objective: It is known that the risk of developing periodontal disease is high in patients with diabetes. In this study, a comparison of the mineral density and structure of calculus in teeth of individuals with diabetes and healthy subjects was aimed at by examining with scanning electron microscopy. Material and Methods: In this study, the teeth of 17 diabetic patients were used. After removal of the soft tissues, teeth were embedded in bakalite and sections were obtained from the region including calculus. Teeth covered with gold-palladium were observed by scanning electron microscope and mineral analysis was performed with energy-dispersive system. Results: The calculus away from homogeneous structure and seen high was being porosities. Intensive cracks in the calculus attaching to the sementum region of control and diabetic groups was also seen tocontinue into the sementum. When the mineral analysis of the control and diabetic groups were compared, there was no significant difference among the proportions of calcium. In diabetics, while the amount of phosphate of calculus in sementum was lower than in the controls, the amount of phosphate in enamel was seen higher than controls and this was statistically significant. Conclusion: While a significant effect of diabetes on formation of calculus and the amount of inorganic material was not shown, there may be deterioration in the structure of sementum depending on the calculus. [ABSTRACT FROM AUTHOR]