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Prestressed concrete continuous beam-arch composite bridge with concrete-filled steel tube is a new type of bridge developed in recent years. It has the characteristics of strong spanning ability and large in-plane stiffness, but the lateral stiffness of the arch ribs for this type of bridge is relatively weak. In order to effectively improve the construction quality and structure stability, and optimize the mechanical properties, and in addition of realize the design of large span continuous beam-arch composite bridge, a comprehensive safety assessment of the Liuxi River bridge during construction and serving stages located in China was conducted in this paper. The results show that the bridge had favorable safety margin during the construction and severing stages. The outcomes of this study can provide technical support for the safety and smooth implementation of the bridge's safeguard, which has important theoretical significance and engineering application value. [ABSTRACT FROM AUTHOR]