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Ischaemia-reperfusion injury (IRI) to the gut following cardiopulmonary resuscitation (CPR) gives rise tolocal effects including altered mucosal permeability and infarction of the gut, and remote consequenceswhich may culminate in multiple organ failure with a potentially fatal outcome. We describe two cases ofIRI to the gut following CPR in patients where diarrhoea and abdominal pain in the first, and haematemesis,rectal bleeding and peritonitis in the second patient were the presenting features. The relevant aspects ofpathophysiology and management are summarised.IRI to the gut, defined as tissue damage occurring as a direct consequence of revascularisation, results fromintestinal hypoperfusion due to cardiogenic, septic, or haemorrhagic shock, the use of vasoactive drugs,supra-coeliac aortic cross-clamping, construction of free intestinal grafts, or a mesenteric embolic event.We describe two cases of IRI to the gut following CPR and summarise the relevant aspects of itspathophysiology and management.Key Words: Ischaemia-reperfusion injury, gut, cardiopulmonary resuscitation.