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Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 探讨按病种分值付费(DIP)医保支付方式对医院骨科4级手术相关医疗质量指标的影 响, 为医院管理质量持续改进提供参考. 方法 选取2020年1月1日至2021年12月31日宿迁市某三甲公立 医院骨科手术患者526例, 其中DIP实施前236例, DIP实施后290例. 根据手术方式将患者分为3组, 其中全 膝关节置换术175例(A 组), 全髋关节置换术129例(B组), 内镜下腰椎间盘切除术222例(C组). 比较3组 DIP实施前后平均住院日、均次住院费用、耗占比变化情况. 结果 3组 DIP实施后平均住院日、均次住院费用 低于 DIP实施前, 差异有统计学意义(P<0.05). 3组 DIP实施后耗占比与 DIP实施前比较, 差异无统计学意 义(P>0.05). 结论 DIP实施后科室医疗服务质量和服务效率有所提高. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore the clinical effect of ultrasonic cleaner combined with tongue brush and scraping in the treatment of halitosis in elderly. Methods A total of 160 elderly patients with halitosis, aged 60 to 75,who attended to the dental clinic of this hospital from May 2019 to May 2021 were selected.All subjects were divided into experimental group A,B,C and the control group, with 40 cases in each group. The patients of control group was treated with chlorhexidine gargle. The patients of experimental group A was treated with tongue brush and scraping. The patients of experimental group B was treated with ultrasonic scaler. The patients of experimental group C was treated with tongue brush, scraping and ultrasonic scaler. The sensory method was used to detect oral rank (OR), and the volatile sulfur compounds (VSCs) detector was used to detect the VSCs value of the patient, while the tongue coating thickness (Tt) and tongue coating area (Ta) were analyzed before and after treatment. The periodontal pocket probing depth (PD) and plaque index (PLI) were detected to explore the relationship between periodontal disease, tongue coating and bad halitosis. Results After treatment, the values of OR and VSCs in the four groups decreased significantly (P＜0.05). There were no significant differences in OR and VSCs between the experimental group A and the control group (P＞0.05). The OR and VSCs values of experimental group B and C were significantly lower than those of the control group and the experimental group A (P＜0.05). The OR and VSCs values of the experimental group C were significantly lower than those of the experimental group B (P＜0.05). The values of Tt, Ta, PD and PLI in the control group had no significant change before and after treatment (P＞0.05). The values of Tt and Ta in the experimental group A and the experimental group C reduced significantly than those before the treatment (P＜0.05), but there was no significant difference between the two groups (P＞0.05). The values of PD and PLI in the experimental group B and C reduced significantly. The values of PD and PLI in the experimental group C after treatment were significantly lower than those of the experimental group B (P＜0.05). The results of correlation analysis showed that VSCs and OR had a significant positive correlation (r=0.852,P＜0.05). VSCs, OR and Ta had a strong positive correlation (r=0.487,0.394,P＜0.05), a weak correlation with Tt (r=0.288,0.265,P＜0.05). OR and PLI had a strong positive correlation (r=0.678,0.524,P＜0.05), and a weak correlation with PD (r=0.257,0.240,P＜0.05). Conclusion The value of OR in the elderly has a positive correlation with the VSCs, Ta and PLI. Ultrasonic cleaner combined with tongue brush and scraping can significantly improve the halitosis of the elderly, reduce the level of VSCs, and improve the level of Tt, Ta, PD and PLI. [ABSTRACT FROM AUTHOR]

Objective To investigate the expression of cyclin B2 (CCNB2) in endometrial cancer, and to explore its correlation with patient prognosis and clinicopathological features. Methods The baseline table of patients with endometrial cancer was made using Xiantao, and the diagnostic value of CCNB2 mRNA in endometrial cancer was evaluated by the receiver operating characteristic curve (ROC). The expression of CCNB2 in endometrial cancer tissues and normal endometrial tissues was analyzed by GeneExpression Profiling Interactive Analysis (GEPIA), Xiantao, and HPA online platform. UALCAN online platform and Kaplan-Meier Plotter curve were used to analyze the relationship between clinical characteristics and prognosis of endometrial cancer. The cBioPortal online platform was used to analyze the mutation of CCNB2 gene in endometrial cancer. The LinkedOmics and WebGestalt online platforms were used to analyze the biological significance of CCNB2 gene, and the search tool for recurring instances of neighbouring genes (STRING) online platform was used to construct the CCNB2 protein interaction network. Results Most of the patients with endometrial cancer were menopausal women over 60 years old, and the pathological stages were mainly stage I. Compared with normal endometrial tissues, CCNB2 mRNA and protein expressions were significantly up-regulated in endometrial cancer tissues. When the cut-off value of CCNB2 mRNA expression was 1. 878, the area under curve (AUC) was 0. 982. CCNB2 mRNA was associated with different stages, age, climacteric status, histological subtype and TP53 mutation status of endometrial cancer. Endometrial cancer patients with high CCNB2 mRNA expression had a worse prognosis. The CCNB2 gene was altered in 3% (17/509) of endometrial cancer patients, with mutations including amplification and increased mRNA. CCNB2 co-expressed genes are mainly related to the process of cell division, and are involved in the positive regulation of mitochondrial adenosine-triphosphate (ATP) synthesis coupled with electron transport, mitotic nuclear membrane decomposition, and the positive regulation of mitotic cell cycle G2/M transition. Conclusion CCNB2 is highly expressed in endometrial cancer and may participate in the cell cycle regulation of endometrial cancer, which could be used as an indicator for early diagnosis and predicting prognosis of endometrial cancer. [ABSTRACT FROM AUTHOR]

Objective To explore the effect of zinc deficiency on oxidative stress and methylation of human normal esophageal epithelial cells (HEEC) induced by N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) .Methods The cells were divided into the normal control group, the zinc-rich group, the positive control group and the zinc-deficient group, and intervened for 12,24 and 48 hours respectively. The levels of malondialdehyde (MDA),superoxide dismutase (SOD),glutathione peroxidase (GSH-Px),methylation status of O6-methylguanine-DNA methyltransferase (MGMT) and MLH1 genes and expression level of MGMT protein were compared in each group. Results The median inhibitory concentration of TPEN on HEEC was 1.0 μmol/L. The levels of MDA and GSH-Px in the four groups at different time points were significantly different (P<0.05) .The level of SOD in the four groups at 12 hours was significantly different (P<0.05) .MGMT and MLH1 genes in the four groups showed partial methylation. The expression level of MGMT protein in the four groups was significantly different at 24 hours (P<0.05),but there was no significant difference at 12 and 48 hours (P>0.05) .Conclusion Zinc deficiency can lead to oxidative stress, methylation of MGMT and MLH1 genes and abnormal expression of MGMT protein in HEEC induced by MNNG. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

研究分娩时母体血清钙离子水平对产后出血的预测价值。方法 选取2017年1月至 2021年1月该院住院分娩且为35岁以下、孕足月、单胎头位顺产的初产妇120例作为研究对象,将血清钙离子 水平低于2.11 mmol/L的孕妇40例作为观察组,血清钙离子水平大于或等于2.11 mmol/L的孕妇40例作为 对照组1,另将第二产程开始予以静脉滴注葡萄糖酸钙(维持血清钙离子水平大于或等于2.11 mmol/L)的孕妇 40例作为对照组2。记录并比较3组产后出血量、第二产程及第三产程所需时间的差异。结果 观察组的产 后出血量明显高于对照组1、对照组2,差异均有统计学意义(P <0.05);其中,观察组的产后出血发生率为 62.5%,对照组1的产后出血发生率为0,对照组2的产后出血发生率为2.5%。观察组第二产程及第三产程所 需时间均多于对照组1、对照组2,差异均有统计学意义(P <0.05)。结论 分娩时维持母体血中的正常钙离子 水平可有效减少产后出血量和降低产后出血发生率,缩短第二产程及第三产程。 [ABSTRACT FROM AUTHOR]

目的通过医学生物化学教学改革， 激发学生学习兴赽， 提升教学质量， 为医学院校该课程教学改革提供参考。 方法对医学生物化学教学从理论、实验课两方面进行改革， 临床一班(49 人）采用改革后教学模式， 二班(51 人）采用传统教学模 式，从理论掌握、实验操作能力等方面观察教学改革成效。结果临床一班的知识掌握程度、对医学生物化学的学习兴趋及自主 学习能力均高于二班， 差异均有统计学意义(P<0.05) 。结论临床一班医学生物化学的教学改革取得了一定效果，教学质量有 所提升， 学生的学习兴趣有所提高，培养了学生的创新思维及综合实践能力。 [ABSTRACT FROM AUTHOR]

Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 研究重症脑卒中患者应用丙氨酰-谷氨酰胺联合神经节苷脂钠治疗的临床效果。方法 选取该院 2016年 7月至 2018年11月收治的56例重症脑卒中患者,按照治疗方案不同分为观察组和对照组,各28例。对照组采取神经节苷脂钠 治疗,观察组采取丙氨酰-谷氨酰胺+神经节苷脂钠治疗。比较2组治疗前后血清 IgM、IgG、IgA、丙二醛 (MDA)、超氧化物歧代 酶(SOD)水平及美国国立卫生院神经功能缺损评分(NIHSS) 评分。结果 治疗6周后,观察组血清 IgM、IgG、IgA 水平较对照组 高,差异有统计学意义(P<0.05);血清 MDA、SOD 水平较对照组低,差异有统计学意义(P<0.05);与对照组相比,观察组 NIHSS 评分较低,差异有统计学意义(P<0.05)。结论 重症脑卒中患者应用丙氨酰-谷氨酰胺联合神经节苷脂钠治疗可显著提高机 体免疫功能,减轻氧化应激反应,加快神经功能改善。 [ABSTRACT FROM AUTHOR]