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Copyright of Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi is the property of Journal of Clinical Hepatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Neonatal acute liver failure is a rare and life-threatening disease in the neonatal period with complete or substantial loss of liver function, and liver cirrhosis can be identified after birth, with a high mortality rate. The main etiologies of this disease include autoimmune liver diseases during pregnancy, viral infection, blood diseases, metabolic diseases, ischemic injury, and other rare causes. At present, etiological treatment is the main treatment method, and liver transplantation is still an important option for patients with unknown etiology or no response to established treatments. Currently there are few studies on neonatal acute liver failure, so prospective studies are needed to investigate the influencing factors for treatment and prognosis. [ABSTRACT FROM AUTHOR]

bjective To investigate the value of liver stiffness measurement( LSM) by transient elastography,aspartate aminotransferase-to-platelet ratio index( APRI),and fibrosis-4( FIB-4) in the diagnosis of liver fibrosis in children with biliary atresia. Methods A total of 110 children with biliary atresia who underwent Kasai operation in Department of Neonatal Surgery,Hunan Children’s Hospital,from January 1,2016 to December 31,2018 were enrolled. Liver biopsy specimens and related clinical data were collected,including routine blood test results,liver function,and transient elastography results. The chi-square test was used for comparison of categorical data between groups. The Kruskal-Wallis H test was used for comparison of non-normally distributed continuous data. MedCalc software was used to plot the receiver operating characteristic( ROC) curve,and the ROC curve was used to evaluate the diagnostic efficiency of LSM,APRI,and FIB-4 in evaluating the degree of liver fibrosis. The Spearman correlation analysis was also performed. Results The ROC curve analysis showed that in the diagnosis of biliary atresia with marked liver fibrosis( F≥2),LSM had an area under the ROC curve( AUC) of 0. 874( 95% confidence interval [CI]: 0. 778-0. 970) at the cut-off value of 9. 250 kPa,APRI had an AUC of 0. 636( 95% CI: 0. 362-0. 911) at the cut-off value of 0. 680,and FIB-4 had an AUC of 0. 622( 95% CI: 0. 363-0. 880) at the cut-off value of 0. 047; in the diagnosis of biliary atresia with progressive liver fibrosis( F≥3),LSM,APRI,and FIB-4 had an AUC of 0. 781( 95% CI: 0. 689-0. 873),0. 519( 95% CI: 0. 401-0. 636),and 0. 506( 95% CI: 0. 389-0. 623),respectively,at the cut-off value of 10. 75 k Pa,0. 70,and 0. 05,respectively; in the diagnosis of biliary atresia with liver cirrhosis( F≥4),LSM,APRI,and FIB-4 had an AUC of0. 855( 95% CI: 0. 769-0. 942),0. 701( 95% CI: 0. 599-0. 803),and 0. 717( 95% CI: 0. 609-0. 825),respectively,at the cut-off value of 11. 85 kPa,0. 82,and 0. 09,respectively. The correlation analysis showed that LSM was positively correlated with aspartate aminotransferase level( r = 0. 258,P = 0. 007) and was negatively correlated with platelet count( r =-0. 248,P = 0. 009). Conclusion Transient elastography has a high accuracy in determining the grade of liver fibrosis in children with biliary atresia,with a higher clinical value than APRI and FIB-4 in evaluating the degree of liver fibrosis. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi is the property of Journal of Clinical Hepatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi is the property of Journal of Clinical Hepatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi is the property of Journal of Clinical Hepatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)