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Hypercalcemia is a rarely seen medical emergency in children compared with adults who present with nonspecific symptoms such as loss of appetite, nausea, vomiting, weight loss. Severe hypercalcemia is a rare complication of malignancy in children which can result in a life threatening condition. Herein, we report a H-year -old girl presenting with a mass on her neck and hypercalcemia. Her serum calcium level was 18.4 mg/dL which necessitated biochemical analysis with resultant establishment of diagnosis of pre B acute lymphoblastic leukemia (ALL) and ensuing venovenous hemofiltration treatment for her acute hypercalcemia. Our aim is to remind that malignancies should not be overlooked in the differential diagnosis of pediatric hypercalcemia. [ABSTRACT FROM AUTHOR]

Methylmalonic acidemia (MMA) is an inherited metabolic disorder that results from deficiency of a vitamin B12- dependent enzyme methylmalonyl-CoA mutase. Lack of this enzyme which converts methylmalonil-CoA to succinyl-CoA and hydrolization to methylmalonic acid leads to increased methylmalonic acid levels in blood and urine. Onset of the clinical manifestations can onset in different ages, and forms. Asymptomatic cases up to adulthood have been reported. The most common clinical forms can be enumerated as acute metabolic decompensation state beginning in the neonatal period, acute intermittant form with asymptomatic intervals between acute episodes and chronic progressive form characterized by hypotonus, developmental, and neuromotor retardation. Herein, we report a 18 month-old female patient diagnosed as late- onset methylmalonic acidemia presenting with neuromotor retardation and convulsion. [ABSTRACT FROM AUTHOR]

In recent years there are threatening reports about allergic reactions and frequent usage of cephalosporins Fatal anaphylaxis after first exposure to cephalosporin is very rare (I ; 100 000). Herein, we report development of anaphylaxis after the first intravenous injection of ceftriaxone in a 8 year- old- male patient who was healthy and did not use ceftriaxone before. We reported this case in order to warm clinicians against the possible risk of anaphylaxis even after the first dose of ceftriaxone and to avoid administration of the drug without indication. [ABSTRACT FROM AUTHOR]