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Background: Obesity is abnormal or excessive fat accumulation linked to increased risk of developing a range of life-limiting illnesses, including heart disease, cancer and type 2 diabetes. Physical wellbeing Is the ability to maintain a healthy quality of life that allows us to get the most out of our daily activities without undue fatigue or physical stress Aim of the study: To assess the effect of obesity on nurses performance and physical wellbeing at Zagazig University Hospitals. Research design: A descriptive design was used. Setting: The study was conducted at Zagazig University Hospitals Subjects: Purposive sample of 80 nurses working at Zagazig University Hospitals. Tools of data collection: Three tools were used for collecting data include an interviewing questionnaire to collect demographic characteristics of the study nurses, questionnaire to evaluate the effect of obesity on physical wellbeing and oswestry Disability Index questionnaire. Results: Shows that 55%of the studied nurses had satisfactory knowledge about obesity.82.5% of the studied nurses obesity affects their total practice.77.5% of the studied nurses obesity affects their total physical well-being.47.5% of the studied nurses had moderate disability. Also, 22.5% of the studied nurses had minimal disability. While, 20% of nurses had severe disability and 10% had crippling back pain. Conclusion: this study can be concluded that more than half of the studied nurses had satisfactory knowledge about obesity, majority of the studied nurses obesity affects their total practice and more than three quarters of the studied nurses obesity affects their total physical well-being. There was significant positive correlation between effect of obesity on nurses’ practice and physical well-being and permanent functional disability. Recommendation: Educational programs should be held periodically for nurses on obesity and negative effect of it on their work life, Urgent training program is required to support nurses to achieve and maintain a healthy weight, Further study is recommended to assess predisposing factor caused obesity among nurses. [ABSTRACT FROM AUTHOR]