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INTRODUCTION: It is very important to find a a non invasive, less time consuming and relatively easy modality, non operator dependent and available even remote areas for the common bile duct stones (choledocolithiasis) in symptomatic patients. Instant diagnosis will lead to prompt decision making for treatment strategies that will ultimately decrease the morbidity. OBJECTIVE: To determine the diagnostic accuracy of ultrasonography in detection of Choledocholithiasis in suspected patients taking intraoperative findings as gold standard. STUDY DESIGN: Descriptive Cross sectional Study SETTING: Department of Radiology, Jinnah postgraduate Medical Center, Karachi DURATION: Six months study from Feb 2020 onwards. SUBJECTS AND METHODS: All patients with age 30-60 years of either gender having clinically suspected with duration of symptoms of more than or equal to 7 days were enrolled. The ultrasound was performed and presence of CBD diameter of > 7 mm on US was taken as CBD stones. Presence of CBD stones intra operatively was noted. RESULTS: Mean age of the patients was 51.29 ±7.03 years. There were 75 (62%) females and 46 (38%) males. Overall diagnostic accuracy of ultrasonography was found to be 89.25%. Sensitivity was found to be 80.48%, specificity 93.75%, PPV 86.84% and NPV 90.36%. CONCLUSION: The diagnostic accuracy of ultrasonography was found satisfactory in detection of Choledocholithiasis in suspected patients taking intraoperative findings as gold standard. [ABSTRACT FROM AUTHOR]