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Aim: The aim of the present study was to assess the deficiency of vitamin B12 in the patients of type 2 diabetes mellitus with peripheral neuropathy and its correlation. Methods: The participants for the present study were recruited from patients with T2DM seen in the South Eastern Railway Central Hospital, Kolkata. The study was conducted for two years. Results: Patients with diabetic neuropathy were older as majority had age between 61-70 years (55.40%) compared to those without neuropathy (majority had age between 51-60 years; 39.80%). The sex distribution between group was significantly different as revealed by the highly significant p value of <0.001. 9.60% of the patients with diabetes neuropathy had vitamin B 12 deficiency compared to control group (1.20%). Diabetes neuropathy patients had mean Vitamin B12 (471.33±168.992), diabetes with no neuropathy patients (479.11±208.121). Subjects in control group had higher Vitamin B12 level compared to remaining two groups. Conclusion: Vitamin B12 deficiency is highly prevalent, especially in patients with diabetic neuropathy. In this study an inverse correlation was found between diabetic neuropathy and the plasma level of vitamin B12. The association between diabetic neuropathy and Vitamin B12 deficiency is of great importance, since diabetic or prediabetic patients diagnosed with diabetic neuropathy may have neuropathy due to vitamin B12 deficiency. [ABSTRACT FROM AUTHOR]

Aim: We assessed whether women were more affected by the dramatic drop in hospital admissions for ACS during the Covid-19 pandemic. Methods: This evaluation is an Institutional Review Board (IRB) exempt retrospective, observational study performed inBurdwan Medical College, Burdwan, West Bengal, India. We performed chart review of 1000 patients who presented to Burdwan Medical College, Burdwan, West Bengal, India Catheterization lab for elective and emergency catheterization for non ACS and ACS [NSTEMI, Unstable angina (UA), STEMI] during a 4-week period from February 26 to March 10 and from March 25 to April 8 and compared with the equivalent weeks in the last year. Results: Out of 1000, only 450 patients underwent cardiac catheterization for acute coronary syndrome. Remaining patients underwent cardiac catheterization for causes other than acute coronary syndrome, such as atrial septal defect closure, pulmonary arterial hypertension to assess hemodynamics in the heart chambers, cardiac myxoma, treatment of valvular heart disease (e.g., transcatheter mitral valve repair), assessment of the congenital heart diseases like cor triatriatum. Conclusion: In conclusion, the pandemic period reduced the gap between men and women in ACS: the extraordinary reduction in admission rates observed during the Covid-19 pandemic seems to have strongly affected women as men, with similar rates of reduction of hospitalized STEMI and NSTEMI and a trend toward greater reduction in UA admission among women. [ABSTRACT FROM AUTHOR]

Aim: The aim of the present study was to evaluate ST elevation myocardial infarction of inferior wall and right ventricle in rheumatic mitral stenosis due to thrombus at right coronary sinus. Methods: The present study was conducted in the Department of cardiology, Burdwan medical college and hospital, West Bengal, India. Acute MI was diagnosed by the presence of at least 2 of the following criteria: electrocardiographic changes, significant rises in myocardial bound creatine kinase fraction, and typical chest pain. Inferior wall MI was diagnosed by electrocardiography, echocardiography and coronary angiography. In patients with non-ST elevation MI, echocardiography and coronary angiographic findings were used for determination of the diagnosis of inferior wall MI. There was total 100 patients included in the present study. Results: Echocardiography was performed within 1.7±1.4 days (range 0-5) after acute MI. There were no differences in age, sex and other frequencies of underlying diseases among the 3 groups. There were no differences in the modality of intervention, severity of coronary artery disease. Fifty-five (73.34%) patients had the culprit lesion in the right coronary artery and 20 (26.6%) patients had the culprit lesion in the left circumflex artery. Patients whose culprit lesion in the left circumflex artery had an increased frequency of more severe MR than those with the culprit lesion in the right coronary artery, but this difference did not reach statistical significance (P=0.420). Conclusion: In the acute phase of inferior wall MI, MR was associated with LV systolic dysfunction with tethering. Therefore, it can be suggested that reduced closing force as a consequence of LV systolic dysfunction in the presence of leaflet tethering would play a more pivotal role in the development of MR in the acute phase of inferior MI, whereas increased tethering forces through a combination of annular dilation and geometric remodeling of the LV would be more important contributor in the chronic phase. [ABSTRACT FROM AUTHOR]