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Covid -19 a virus caused by novel severe acute respiratory syndrome. It belongs to genus -- Bettacoronavirus and family-Coronaviridae. In most of countries pandemic occurred due to this virus, in Dec 2019 an upsurge of covid-19 occurred in Wuhan city of China. WHO declared as public health emergency of international in the month of Jan 2020? Covid-19 a RNA dependent virus which is composed of cap of crown like structure and spike like protein located at outer part of virus these spikes are composed of glycoprotein .Various enzymes are in maturation of life cycle of virus such chymotrypsin like protease, therefore main target for antiviral activity. The emerging trend of Remdesivir a broad spectrum antiviral drug which shows potent effect in inhibiting viral replication. Initialisation stage of attachment of virus through spike protein into host cell is also inhibited. In recent study combination of Mycophenolic acid acyl glucronic with Remdesivir shows the potent inhibitory effect on Covid-19. The side effects are not clear but in some clinical study acute inflammatory disease of kidney are seen. As this drug after showing their inhibitory actions on viral replication also suppress the production of cytokines and due to over suppression leads to cytokine mediated inflammatory disease. [ABSTRACT FROM AUTHOR]