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Covid -19 a virus caused by novel severe acute respiratory syndrome. It belongs to genus -- Bettacoronavirus and family-Coronaviridae. In most of countries pandemic occurred due to this virus, in Dec 2019 an upsurge of covid-19 occurred in Wuhan city of China. WHO declared as public health emergency of international in the month of Jan 2020? Covid-19 a RNA dependent virus which is composed of cap of crown like structure and spike like protein located at outer part of virus these spikes are composed of glycoprotein .Various enzymes are in maturation of life cycle of virus such chymotrypsin like protease, therefore main target for antiviral activity. The emerging trend of Remdesivir a broad spectrum antiviral drug which shows potent effect in inhibiting viral replication. Initialisation stage of attachment of virus through spike protein into host cell is also inhibited. In recent study combination of Mycophenolic acid acyl glucronic with Remdesivir shows the potent inhibitory effect on Covid-19. The side effects are not clear but in some clinical study acute inflammatory disease of kidney are seen. As this drug after showing their inhibitory actions on viral replication also suppress the production of cytokines and due to over suppression leads to cytokine mediated inflammatory disease. [ABSTRACT FROM AUTHOR]

The aim of this study to Review role of Hydroxy chloroquine Coronavirus pandemic is presently a universal public health emergency. At present, no pharmacological treatment is known to treat this condition, and there is a need to review the available treatment. We intended to analyze the role of hydroxychloroquine remedy in mildly symptomatic patients. Hydroxychloroquine has been shown to prohibit entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into epithelial cells in vitro, but clinical studies found no evidence of reduced fatality when treating patients with COVID-19. We intended to check out the effectiveness of hydroxychloroquine for prevention of COVID-19 mortality. In this study we discussed about the Mechanism of action, preparation of drug, side effects and drug interactions A recent observational though reported improved survival when HCQ is given within 2 days of Hospitalization . It has been seen that early administration of HCQ could delay the advancement to more serious illness requiring hospitalization.In this study we discussed about their Anti viral activity which are helpful in the covid-19, their anti malarial activity and also highlights their medicinal uses [ABSTRACT FROM AUTHOR]

The objective of this study is to review a current goal of all the researchers to look in-forward. As per the all-current research no accurate treatment out-there but since from the date SARS-COV-2 is declared as a Pandemic the use of Re-purposed drug as per the clinical data have proven effective in some case but It's not a permanent treatment to treat. Researchers are dealing to find the permanent regimen to treat the Covid-19 by developing a vaccine which are in different phases. This Review has an Eagle Eye on the treatment used to treat the SARS-COV-2 since from the starting. It contains the information on structure of Covid-19, lethality along with the description of re-purposed drug with its mechanism and the efficacy as per data and the vaccines which are currently approved till date and are employed for the treatment globally. [ABSTRACT FROM AUTHOR]