1. Pneumonia treatment by photodynamic therapy with extracorporeal illumination ‐ an experimental model
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Vanderlei Salvador Bagnato, Natalia Mayumi Inada, Cristina Kurachi, Mariana Carreira Geralde, Wolfgang M. Kuebler, Ana Carolina Guerta Salina, Alexandra Ivo de Medeiros, Ilaiáli Souza Leite, Universidade de São Paulo (USP), Universidade Federal de São Carlos (UFSCar), Universidade Estadual Paulista (Unesp), and St Michaels Hosp
- Subjects
0301 basic medicine ,Indocyanine Green ,030103 biophysics ,medicine.medical_specialty ,Pathology ,indocyanine green ,Physiology ,medicine.drug_class ,medicine.medical_treatment ,Antibiotics ,Immunology ,Photodynamic therapy ,medicine.disease_cause ,Gastroenterology ,Extracorporeal ,030207 dermatology & venereal diseases ,03 medical and health sciences ,chemistry.chemical_compound ,Mice ,0302 clinical medicine ,Physiology (medical) ,Internal medicine ,parasitic diseases ,Streptococcus pneumoniae ,STREPTOCOCCUS ,medicine ,pneumonia ,Animals ,Photosensitizer ,Original Research ,Respiratory Conditions Disorder and Diseases ,Lung ,Extracorporeal illumination ,Photosensitizing Agents ,business.industry ,Phototherapy ,Pneumonia, Pneumococcal ,medicine.disease ,eye diseases ,Pneumonia ,Disease Models, Animal ,medicine.anatomical_structure ,Treatment Outcome ,chemistry ,photodynamic therapy ,Photochemotherapy ,business ,Indocyanine green - Abstract
Made available in DSpace on 2018-11-26T15:43:53Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-03-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Infectious pneumonia is a major cause of morbidity/mortality, mainly because of the increasing rate of microorganisms resistant to antibiotics. Photodynamic Therapy (PDT) is emerging as a promising approach, as effects are based on oxidative stress, preventing microorganism resistance. In two previous studies, the in vitro inactivation of Streptococcus pneumoniae using indocyanine green (ICG) and infrared light source was a success killing 5 log10 colony-forming units (CFU/mL) with only 10 lmol/L ICG. In this work, a proof-of-principle protocol was designed to treat lung infections by PDT using extracorporeal illumination with a 780 nm laser device and also ICG as photosensitizer. Hairless mice were infected with S. pneumoniae and PDT was performed two days after infection. For control groups, CFU recovery ranged between 10(3)-10(4) / mouse. For PDT group, however, no bacteria were recovered in 80% of the animals. Based on this result, animal survival was evaluated separately over 50 days. No deaths occurred in PDT group, whereas 60% of the control group died. Our results indicate that extracorporeal PDT has the potential for pneumonia treatment, and pulmonary decontamination with PDT may be used as a single therapy or as an antibiotics adjuvant. Univ Sao Paulo, Sao Carlos, SP, Brazil Univ Fed Sao Carlos, Sao Carlos, SP, Brazil Sao Paulo State Univ, Araraquara, Brazil St Michaels Hosp, Keenan Res Ctr, Toronto, ON, Canada Sao Paulo State Univ, Araraquara, Brazil FAPESP: 13/07276-1 CAPES: 99999.003154/2015-07
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- 2017