1. Clinical exacerbation of SARS‐CoV2 infection after fingolimod withdrawal
- Author
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Paloma Montero-Escribano, Víctor Gómez-Mayordomo, Jorge Matías-Guiu, Nuria González-García, Jordi A. Matías-Guiu, and Jesús Porta-Etessam
- Subjects
Drug ,Male ,Exacerbation ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,media_common.quotation_subject ,Short Communication ,Short Communications ,coronavirus ,medicine.disease_cause ,multiple sclerosis ,SARS‐CoV‐2 ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,exacerbation ,Multiple Sclerosis, Relapsing-Remitting ,COVID‐19 ,Virology ,medicine ,Humans ,030212 general & internal medicine ,fingolimod ,media_common ,Coronavirus ,Inflammation ,business.industry ,Fingolimod Hydrochloride ,SARS-CoV-2 ,Multiple sclerosis ,COVID-19 ,Middle Aged ,medicine.disease ,Fingolimod ,Discontinuation ,Infectious Diseases ,Immunology ,RNA, Viral ,030211 gastroenterology & hepatology ,business ,Immunosuppressive Agents ,medicine.drug - Abstract
The role of disease‐modifying therapies in patients with autoimmune disorders during SARS‐CoV2 infection is controversial. Immunocompromised patients could have a more severe COVID‐19 disease, due to the absence of an adequate immune response against the SARS‐CoV‐2. However, therapies that act on immune response could play a protective role by dampening the cytokine release syndrome. Fingolimod is a drug used for immune therapy in patients with Multiple Sclerosis (MS) through the sequestration of activated lymphocytes in the lymph nodes. We report the case of a 57‐year‐old man with relapsing‐remitting MS treated with fingolimod that showed a reactivation of COVID‐19 with signs of hyperinflammation syndrome after fingolimod withdrawal. Our case suggests that discontinuation of fingolimod during COVID‐19 could imply a worsening of SARS‐CoV2 infection. This article is protected by copyright. All rights reserved.
- Published
- 2020