1. Optical coherence tomography and molecular analysis of sudden acquired retinal degeneration syndrome (SARDS) eyes suggests the immune‐mediated nature of retinal damage
- Author
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Markus H. Kuehn, Tatjana Lazic, Helga Kecova, Kabhilan Mohan, and Sinisa D. Grozdanic
- Subjects
Male ,retina ,genetic structures ,Radiography ,0403 veterinary science ,chemistry.chemical_compound ,0302 clinical medicine ,Prevalence ,Dog Diseases ,medicine.diagnostic_test ,Retinal Degeneration ,sudden acquired retinal degeneration syndrome ,04 agricultural and veterinary sciences ,Syndrome ,Immunohistochemistry ,Pedigree ,medicine.anatomical_structure ,Original Article ,Female ,Erg ,microarray ,Tomography, Optical Coherence ,medicine.medical_specialty ,Canada ,040301 veterinary sciences ,canine ,03 medical and health sciences ,Dogs ,Optical coherence tomography ,Ophthalmology ,medicine ,Electroretinography ,Animals ,Retina ,optical coherence tomography ,General Veterinary ,business.industry ,Histology ,Retinal ,Original Articles ,eye diseases ,United States ,chemistry ,Case-Control Studies ,detachment ,030221 ophthalmology & optometry ,Sudden acquired retinal degeneration ,sense organs ,immune ,business - Abstract
Objective To perform detailed analysis of retinal changes in dogs with SARDS using optical coherence tomography (OCT), funduscopy, and molecular analysis. Animals Subjects were 29 dogs from 12 US states and Canada diagnosed with SARDS by 8 ophthalmologists. An additional 7 eyes from 5 deceased SARDS dogs were used for molecular and histological analysis. Procedures Dogs were evaluated using chromatic pupil light reflex testing (cPLR), and electroretinography (ERG); subjects underwent complete ophthalmic examination, including funduscopy, retinal photography, and OCT, in addition to complete laboratory analysis, blood pressure evaluation, abdominal and thoracic radiographs, and computerized tomography (CT) imaging to assess possible systemic abnormalities. Histology and immunohistochemistry analysis was performed in 2 SARDS eyes. Microarray analysis was performed in 5 SARDS retinas. Results Thirty‐eight percent of patients had
- Published
- 2018