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Glucose, sucrose, starch, and locust bean gum have been used as additives to the ferrous-agarose-xylenol orange (FAX) gel dosimeter. The saccharide enhanced dosimeters were found to have a higher dose sensitivity over a standard FAX gel as measured by both optical density change and magnetic resonance imaging (MRI). With optical density measurement, OD-dose sensitivity increases were up to 55% for glucose, 122% for sucrose and 43% for starch, while locust bean gum did not give a consistent response. With MRI, R1-dose sensitivity increases were up to 178% with sucrose addition. The FAX gel with sucrose was studied in greatest detail. The OD-dose sensitivity dependence on cooling rate was reduced for the sucrose FAX gel over the standard FAX gel, which has significant implications for uniform dose sensitivity in large gel phantoms. The thermal oxidation rate in the sucrose FAX gel was up to 2.3 times higher than in the standard gel. The OD-dose sensitivity of oxygenated sucrose FAX gels was 4.3 times greater than standard FAX gels, while continued enhancement in OD-dose sensitivity with increased sucrose concentrations beyond 2.0 g/l was found only for the oxygenated sucrose FAX gels. Both the molar absorption coefficient of the ferric ion-xylenol orange complex at 543 nm and gel pH were not affected by the presence of sucrose, with the implication that the higher OD-dose sensitivity of gels with saccharides is due to increased chain reaction production of ferric ions.

The spatial accuracy of magnetic resonance imaging (MRI) Fricke-gel dosimetry is limited by diffusion of ferric ions. This paper describes a honeycomb structure to limit diffusion of Fe3+ ions in a three-dimensional phantom. Such a phantom containing the dosimeter gel was irradiated to a known dose distribution. Maps of dose distributions were produced from the MR images acquired at 2 and 24 hours after the dose was given. The dose distribution maps verified that the honeycomb structure precludes ion diffusion from one honeycomb cell to another, thus improving the usefulness of MRI Fricke-gel dosimetry.

The ferrous sulfate-doped gel dosimeters have been developed for three-dimensional magnetic resonance imaging of radiation dose distributions. When the gel dosimeter is irradiated, ferrous ions are converted to ferric ions and the nuclear magnetic spin relaxation of the dosimeter varies with dose. In this paper, a model is presented for the dose dependence of the spin-lattice relaxation rate R1 of the ferrous sulfate doped-gelatin dosimeter. The model is based on three basic physical quantities: the ferric ion yield and the ferrous and ferric ion relaxivities, r2+ and r3+, respectively. These relaxivities specify the ability of the ions to enhance the spin-lattice relaxation of water protons. The effects of gelatin and sulfuric acid concentration on the ferric ion yield and ion relaxivities are presented. The measured r2+ values agree with those predicted by a model in which the measured spin relaxation is considered the result of the fast exchange of water hydrating the ferrous ion with water in the bulk. The r3+ values are lower than predicted by the fast exchange model. The discrepancies in the measured and predicted r3+ values are shown to result from the complexing of ferric ions arising from pH variation caused by changes in gelatin or sulfuric acid concentrations. A modified version of the R1-dose response model accounting for ferric ion complexing is presented and tested spectrophotometrically.

The spin-lattice relaxation rate R1(= T1(-1) of irradiated Fricke solution was studied as a function of the absorbed dose D. The R1 increases linearly with dose up to D approximately 400 Gy after which the response saturates. A model describing the R1 of a solution of either ferrous (Fe2+) or ferric (Fe3+) ions is presented; it is based on the spin relaxation of protons on water molecules in the bulk and protons on water molecules in the coordination shells of the ions with fast exchange occurring between the two water environments. All inherent relaxation parameters of the different proton groups are determined empirically at NMR frequencies of 9 and 25 MHz. An extension of the model is made to describe the spin-lattice relaxation behavior of irradiated Fricke solution. Good agreement between model predictions and experimental results is observed. The model relates the spin-lattice relaxation rate of a Fricke dosimeter to the chemical yield of ferric ion, thus potentially creating an absolute NMR dosimetry technique. Various practical aspects of the NMR-Fricke system, such as the optimal initial ferrous concentration and the NMR frequency dependence of the sensitivity, are described.