1. IL4 and IL13 receptors share the gamma c chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells.
- Author
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Rolling C, Treton D, Pellegrini S, Galanaud P, and Richard Y
- Subjects
- Antigens, CD chemistry, B-Lymphocytes immunology, Child, Humans, Immunoglobulin Constant Regions immunology, Immunoglobulin gamma-Chains immunology, Interleukin-13 metabolism, Interleukin-13 Receptor alpha1 Subunit, Interleukin-4 metabolism, Janus Kinase 1, Janus Kinase 3, Phosphorylation, Protein-Tyrosine Kinases metabolism, Receptors, Interleukin chemistry, Receptors, Interleukin-13, Receptors, Interleukin-2 immunology, Receptors, Interleukin-4, Recombinant Proteins metabolism, STAT3 Transcription Factor, STAT5 Transcription Factor, STAT6 Transcription Factor, Time Factors, Tyrosine metabolism, Antigens, CD metabolism, B-Lymphocytes metabolism, DNA-Binding Proteins metabolism, Milk Proteins, Receptors, Interleukin metabolism, Trans-Activators metabolism
- Abstract
IL13 induces the same biological effects as IL4 in normal human B cells. We show that as in the IL4R complex, both IL4R alpha and IL2R gamma c are components of the IL13R and that both cytokines induced STAT6, STAT3 and STAT5 activation in B cells. In spite of this similar downstream signalling, IL4 and IL13 used a different set of Janus kinases: IL13 is unable to activate JAK1 and JAK3.
- Published
- 1996
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