1. Fluoro-modified chemotactic peptides: fMLF analogues.
- Author
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Koksch B, Dahl C, Radics G, Vocks A, Arnold K, Arnhold J, Sieler J, and Burger K
- Subjects
- Fluorescence, Humans, Kinetics, Magnetic Resonance Spectroscopy, Molecular Structure, N-Formylmethionine Leucyl-Phenylalanine chemical synthesis, N-Formylmethionine Leucyl-Phenylalanine chemistry, Neutrophils cytology, Neutrophils drug effects, Peptides chemical synthesis, Protein Structure, Tertiary, Chemotaxis drug effects, N-Formylmethionine Leucyl-Phenylalanine analogs & derivatives, N-Formylmethionine Leucyl-Phenylalanine pharmacology, Peptides chemistry, Peptides pharmacology
- Abstract
A small library of peptide analogues of the chemotactic tripeptide For-Met-Leu-Phe-NH2 modified by substitution of Leu at position 2 by three different fluorinated amino acids varying in content of fluorine, length of the fluorinated side chain, and alkylation degree at the alpha-carbon atom was synthesized. The influence of the fluorine substitution on the biological activity was investigated by measuring the oxidative activity of neutrophils using a luminol-dependent chemiluminescence assay.
- Published
- 2004
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