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1. The value of in vitro studies in a case of neonatal diabetes with a novel Kir6.2-W68G mutation.

Author

O'Connell SM, Proks P, Kramer H, Mattis KK, Sachse G, Joyce C, Houghton JA, Ellard S, Hattersley AT, Ashcroft FM, and O'Riordan SM

Abstract

In infants, especially with novel previously undescribed mutations of the KATP channel causing neonatal diabetes, in vitro studies can be used to both predict the response to sulphonylurea treatment and support a second trial of glibenclamide at higher than standard doses if the expected response is not observed.

Published
2015
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