1. Electrodiagnosis of reversible conduction failure in Guillain-Barré syndrome.
- Author
-
Chan YC, Punzalan-Sotelo AM, Kannan TA, Shahrizaila N, Umapathi T, Goh EJH, Fukami Y, Wilder-Smith E, and Yuki N
- Subjects
- Autoantibodies blood, Female, Gangliosides immunology, Guillain-Barre Syndrome blood, Guillain-Barre Syndrome pathology, Humans, International Cooperation, Male, Muscle, Skeletal physiopathology, Retrospective Studies, Electrodiagnosis, Evoked Potentials, Motor physiology, Guillain-Barre Syndrome physiopathology, Neural Conduction physiology
- Abstract
Introduction: In this study we propose electrodiagnostic criteria for early reversible conduction failure (ERCF) in axonal Guillain-Barré syndrome (GBS) and apply them to a cohort of GBS patients., Methods: Serial nerve conduction studies (NCS) were retrospectively analyzed in 82 GBS patients from 3 centers. The criteria for the presence of ERCF in a nerve were: (i) a 50% increase in amplitude of distal compound muscle action potentials or sensory nerve action potentials; or (ii) resolution of proximal motor conduction block with an accompanying decrease in distal latencies or compound muscle action potential duration or increase in conduction velocities., Results: Of 82 patients from 3 centers, 37 (45%) had ERCF, 21 (26%) had a contrasting evolution pattern, and 8 (10%) had both. Sixteen patients did not show an amplitude increase of at least 50%., Conclusion: Our proposed criteria identified a group of patients with a characteristic evolution of NCS abnormality that is consistent with ERCF. Muscle Nerve 56: 919-924, 2017., (© 2017 Wiley Periodicals, Inc.)
- Published
- 2017
- Full Text
- View/download PDF