1. Modeling and simulation approaches for cardiovascular function and their role in safety assessment
- Author
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Michael J. Chappell, Tariq Abdulla, Teresa Collins, Linnéa Bergenholm, James W.T. Yates, Neil D. Evans, and Jerome T. Mettetal
- Subjects
0303 health sciences ,RM ,business.industry ,media_common.quotation_subject ,Review ,030204 cardiovascular system & hematology ,Data science ,3. Good health ,Modeling and simulation ,03 medical and health sciences ,0302 clinical medicine ,Risk analysis (engineering) ,Safety risk ,Modeling and Simulation ,Medicine ,Pharmacology (medical) ,business ,Function (engineering) ,030304 developmental biology ,media_common ,Systems pharmacology - Abstract
Systems pharmacology modeling and pharmacokinetic-pharmacodynamic (PK/PD) analysis of drug-induced effects on cardiovascular (CV) function plays a crucial role in understanding the safety risk of new drugs. The aim of this review is to outline the current modeling and simulation (M&S) approaches to describe and translate drug-induced CV effects, with an emphasis on how this impacts drug safety assessment. Current limitations are highlighted and recommendations are made for future effort in this vital area of drug research.
- Published
- 2015