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Accessible summary: What is known on the subject?: Aggression and violence are persistent problems in psychiatric inpatient units.Violence preventive factors have been identified from both staff's and patients' perspectives.Violent and aggressive inpatient incidents have not been adequately explained in research and reviews to date. What this paper adds to existing knowledge?: This review is novel in that it provides a comparison of patients' and staff's perspectives and identified that these differ and were influenced by factors attributable to the inpatient culture.The one contributory factor both agreed upon was the role of staff's interpersonal skills in either exacerbating or de‐escalating aggression and violence.The inpatient culture was found to engender differing perceptions of most contributory factors to violence and aggression. What are the implications for practice?: While staff's interpersonal skills were identified as a primary influence on whether their interaction with patients contributed to aggression and violence, this was shaped by the inpatient environment's culture.Patient‐centred interactional skills need to focus on the patients' needs for respect and active participation rather than engendering feelings of disrespect or coercion.Patient‐centred communication skills that demonstrate an understanding of the patient's experience in the inpatient environment need to be core skills for mental health nurses. Introduction: High rates of aggression and violence are a persistent problem in inpatient mental health environments. A comparison of staff's and patients' perceptions of the causes may provide novel insights. Aim: This review aimed to compare patients' and staff's perspectives on the causes of aggression and violence in inpatient environments. Method: An integrative review of the literature was conducted with a search of Ovid (Medline, Embase, PsycINFO) databases and manual searching. Results: Thirty articles met criteria for inclusion. Interactions prior to aggressive or violent incidents were characterized by patients as disrespectful and coercive, and by staff as indicative of the patient's mental state or personality. Both groups identified the importance of patient‐centred communication skills. Discussion: The review identified that patients and staff have differing perspectives on the causes of violence and aggression. There was an interactional dynamic between staff and patients that was shaped by the culture of the inpatient setting. Implications for Practice: Understanding how the inpatient culture plays a role in shaping a dynamic between patients and staff and developing communication skills that acknowledge this may help reduce violence and aggression in inpatient settings. [ABSTRACT FROM AUTHOR]