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1. Complete morphologic and molecular remission after introduction of dasatinib in the treatment of a pediatric patient with t-cell acute lymphoblastic leukemia and ABL1 amplification.

Author

Crombet O, Lastrapes K, Zieske A, and Morales-Arias J

Subjects
Child, Dasatinib, Female, Humans, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma pathology, Remission Induction, Gene Amplification, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma drug therapy, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma genetics, Protein Kinase Inhibitors therapeutic use, Proto-Oncogene Proteins c-abl genetics, Pyrimidines therapeutic use, Thiazoles therapeutic use
Abstract

T-cell acute lymphoblastic leukemia (ALL) accounts for 15% of ALL cases in children and has been associated with a worse prognosis. Cytogenetic studies show an abnormal karyotype in 50-60% of the T-cell ALL patients; ABL1 fusions are present in approximately 8% of the cases. Dasatinib, a second-generation tyrosine kinase inhibitor, directly targets the BCR-ABL gene. We describe a pediatric case of T-cell ALL with amplification of the ABL1 gene in which remission was achieved only after the addition of dasatinib to conventional chemotherapy., (Copyright © 2011 Wiley Periodicals, Inc.)

Published
2012
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