1. Pannexin1 Channel-Mediated Inflammation in Acute Ischemic Stroke.
- Author
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Huang Y, Shi Y, Wang M, Liu B, Chang X, Xiao X, Yu H, Cui X, and Bai Y
- Subjects
- Humans, Animals, Receptors, Purinergic P2X7 metabolism, Receptors, Purinergic P2X7 genetics, Inflammasomes metabolism, NLR Family, Pyrin Domain-Containing 3 Protein metabolism, NLR Family, Pyrin Domain-Containing 3 Protein genetics, Brain Ischemia metabolism, Brain Ischemia immunology, Connexins metabolism, Connexins genetics, Nerve Tissue Proteins metabolism, Nerve Tissue Proteins genetics, Ischemic Stroke metabolism, Ischemic Stroke immunology, Ischemic Stroke genetics, Inflammation metabolism
- Abstract
Emerging evidence suggests that inflammation mediated by the pannexin1 channel contributes significantly to acute ischemic stroke. It is believed that the pannexin1 channel is key in initiating central system inflammation during the early stages of acute ischemic stroke. Moreover, the pannexin1 channel is involved in the inflammatory cascade to maintain the inflammation levels. Specifically, the interaction of pannexin1 channels with ATP-sensitive P2X7 purinoceptors or promotion of potassium efflux mediates the activation of the NLRP3 inflammasome, triggering the release of pro-inflammatory factors such as IL-1 and IL-18, exacerbating and sustaining inflammation of brain. Also, increased release of ATP induced by cerebrovascular injury activates pannexin1 in vascular endothelial cells. This signal directs peripheral leukocytes to migrate into ischemic brain tissue, leading to an expansion of the inflammatory zone. Intervention strategies targeting pannexin1 channels may greatly alleviate inflammation after acute ischemic stroke to improve this patient population's clinical outcomes. In this review, we sought to summarize relevant studies on inflammation mediated by the pannexin1 channel in acute ischemic stroke and discussed the possibility of using brain organoid-on-a-chip technology to screen miRNAs that exclusively target the pannexin1 channel to provide new therapeutic measures for targeted regulation of pannexin1 channel to reduce inflammation in acute ischemic stroke.
- Published
- 2024
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