1. Immune complex glomerulonephritis of suspected iatrogenic origin in five Japanese Black calves
- Author
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Daniel P. Shaw, Angela B. Royal, Véronique Bernier Gosselin, Tim J. Evans, Brian M. Shoemake, Dusty W. Nagy, John R. Middleton, and Dae Y. Kim
- Subjects
Salmonella typhimurium ,0301 basic medicine ,Salmonella Vaccines ,040301 veterinary sciences ,Cattle Diseases ,Physiology ,Active immunization ,vasculitis ,0403 veterinary science ,03 medical and health sciences ,Hypoproteinemia ,Hyperphosphatemia ,Glomerulonephritis ,vaccine ,Internal Medicine ,medicine ,Animals ,Hypoalbuminemia ,Proteinuria ,biology ,General Veterinary ,nephrotic syndrome ,business.industry ,04 agricultural and veterinary sciences ,Note ,medicine.disease ,030104 developmental biology ,biology.protein ,Cattle ,Immunization ,proteinuria ,medicine.symptom ,Antibody ,business ,Nephrotic syndrome - Abstract
Five Japanese Black embryo transfer calves from a single embryo flush, 30 to 45-days-old, including 4 live animals for clinical examination and 1 dead for necropsy, were presented with a history of decreased milk intake and hypoproteinemia. Consistent clinicopathological abnormalities in the 4 calves presented for clinical evaluation included hyperkalemia, hyperphosphatemia, hypoproteinemia, hypoalbuminemia, hyperbilirubinemia, increased creatine phosphokinase activity, and proteinuria. Four calves ultimately were necropsied and all had histologic evidence of immune complex glomerulonephritis. Glomerulonephritis in these calves was hypothesized to have resulted from the interaction of passively acquired antibodies at birth and active immunization at 7 and 28 days of age with a Salmonella Typhimurium core antigen vaccine.
- Published
- 2018
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