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Nebulization is usually used to remove sputum after surgery. We report on a patient with a high fever resulting from the use of Elase® for postoperative nebulization. The patient was a 66-year-old man who had preoperatively received chemotherapy and radiation therapy for a diagnosis of left cheek mucosal carcinoma. On the 31st treatment day, Elase®; was administered for radiation stomatitis. Rhinocleisis was treated by an otoraryngologist, who gave nebulization for 2 days, but no side effects occurred. Nebulization was resumed 8 days after resection of the tumor, and a fever higher than 38°C developed. Postoperative infection was suspected as the cause of the recurrent high fever. However, the fever did not subside after altering the antibiotic regimen. No pathogen was detected on blood culture analysis. The fever resided after the cessation of nebulization. A strong positive reaction to Elase® was noted on an intradermal test. Hence, we concluded that the fever was caused by an allergic reaction to Elase®.