1. Chronic Hepatitis C Treatment with Daclatasvir Plus Asunaprevir Does Not Lead to a Decreased Quality of Life
- Author
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Michiaki Okada, Norimasa Araki, Megumi Kawakubo, Akemi Koga, Taiga Otsuka, Syunya Nakashita, Satoshi Oeda, Yuichiro Eguchi, and Shinji Iwane
- Subjects
Male ,hepatitis C virus ,Longitudinal study ,Pyrrolidines ,Hepacivirus ,chemistry.chemical_compound ,0302 clinical medicine ,Quality of life ,health related quality of life ,Medicine ,Longitudinal Studies ,Prospective Studies ,Prospective cohort study ,Lead (electronics) ,direct acting antiviral treatment ,Aged, 80 and over ,Sulfonamides ,Imidazoles ,Valine ,General Medicine ,Middle Aged ,humanities ,Treatment Outcome ,030220 oncology & carcinogenesis ,Drug Therapy, Combination ,Female ,Original Article ,030211 gastroenterology & hepatology ,medicine.drug ,Adult ,medicine.medical_specialty ,Daclatasvir ,Combination therapy ,Antiviral Agents ,03 medical and health sciences ,Chronic hepatitis ,Internal medicine ,Internal Medicine ,Humans ,Aged ,business.industry ,daclatasvir plus asunaprevir ,Hepatitis C, Chronic ,Isoquinolines ,chemistry ,Chronic Disease ,Quality of Life ,Asunaprevir ,Carbamates ,business - Abstract
Objective The aim of this study was to determine if direct-acting antiviral (DAA) treatment with daclatasvir (DCV) plus asunaprevir (ASV) for 24 weeks influenced the health-related quality of life (HRQOL) at 12 and 24 weeks after treatment initiation [end of treatment (EOT)]. Methods This was a prospective, longitudinal study comparing the HRQOL of patients receiving DAA treatment at 12 weeks after treatment initiation and EOT with the HRQOL at baseline. We used a Japanese-validated version of the 8-item Short Form Health Survey (SF-8) to assess the HRQOL of patients. This score can be compared to the Japanese normative sample scores of SF-8. Wilcoxon signed-rank tests were used to compare the HRQOL before treatment, 12 weeks after treatment initiation, and at EOT. Patients We enrolled patients who received 24-week combination therapy using DCV and ASV for HCV at Saga University Hospital between November 2014 and July 2015. Those who discontinued treatment due to relapse or adverse reactions during the treatment period were excluded from the study. Results There were no significant changes in any of the SF-8 subscales, Physical component scores (PCS) or mental component scores (MCS) during the treatment period for both males and females. Conclusion Our study makes a significant contribution to the literature because 24-week DAA treatment with DCV plus ASV did not decrease the HRQOL at 12 or 24 weeks after treatment initiation. more...
- Published
- 2018
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