1. Pancreatic Acinar Cell Carcinoma with Multiple Liver Metastases Effectively Treated by S-1 Chemotherapy
- Author
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Kazuhiro Kikuta, Shin Miura, Tooru Shimosegawa, Tatsuhide Nabeshima, Atsushi Masamune, Masamichi Ueno, Atsushi Kanno, Seiji Hongo, Kiyoshi Kume, Shin Hamada, Tetsuya Takikawa, and Naoki Yoshida
- Subjects
acinar ,Antimetabolites, Antineoplastic ,medicine.medical_specialty ,Cirrhosis ,Liver atrophy ,liver cirrhosis ,medicine.medical_treatment ,Case Report ,chemotherapy ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Esophageal varices ,Internal medicine ,Ascites ,Internal Medicine ,medicine ,Humans ,Endoscopic Ultrasound-Guided Fine Needle Aspiration ,Aged ,Tegafur ,Chemotherapy ,Carcinoma, Acinar Cell ,business.industry ,Liver Neoplasms ,Cancer ,Acinar cell carcinoma ,General Medicine ,medicine.disease ,Pancreatic Neoplasms ,Drug Combinations ,Oxonic Acid ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,medicine.symptom ,business ,Pancreatic Acinar Cell Carcinoma - Abstract
A 79-year-old woman was referred for pancreatic tail cancer with multiple liver metastases. The pancreatic tail tumor was diagnosed as acinar cell carcinoma (ACC) histologically by endoscopic ultrasound-guided fine-needle aspiration. Because of multiple liver metastases, S-1 chemotherapy was administered, resulting in a partial response to chemotherapy one year later. After approximately three years, liver atrophy and esophageal varices developed. We suspected S-1 as the cause of the liver cirrhosis. S-1 cessation minimized ascites and improved the esophageal varices. Although S-1 can potentially treat ACC, we should be watchful for liver cirrhosis caused by its long-term administration.
- Published
- 2018