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Your search keyword '"Hajime Honjo"' showing total 2 results
Start Over Author "Hajime Honjo" Publisher japanese society of internal medicine
2 results on '"Hajime Honjo"'

2. Ulcerative Colitis-associated Spondyloarthritis Successfully Treated with Infliximab in the Absence of Enhanced TNF-α Responses

Author

Shunsuke, Fujita, Hajime, Honjo, Ryutaro, Takada, Akane, Hara, Yasuhiro, Masuta, Yasuo, Otsuka, Kohei, Handa, Kosuke, Minaga, Shigeyoshi, Tsuji, Masatoshi, Kudo, and Tomohiro, Watanabe

Subjects
Internal Medicine, General Medicine
Abstract

Although concurrent occurrence of spondyloarthritis (SpA) and ulcerative colitis (UC) is sometimes seen, the profiles of cytokines have been poorly understood in UC-associated SpA. We herein report a case of UC-associated SpA successfully treated with infliximab. Profiles of cytokines in the serum and colonic mucosa were characterized by an enhanced expression of IL-6 but not TNF-α. Successful induction of remission by infliximab was associated with the downregulation of IL-6 expression but no significant alteration in TNF-α expression. These findings suggest that some cases of UC-associated SpA might be driven by IL-6, and infliximab might be effective in cases lacking enhanced TNF-α responses.

Published
2023
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