1. Anti-SARS CoV-2 IgG in COVID-19 Patients with Hematological Diseases: A Single-center, Retrospective Study in Japan
- Author
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Takayuki, Fujii, Masao, Hagihara, Keiko, Mitamura, Shiori, Nakashima, Shin, Ohara, Tomoyuki, Uchida, Morihiro, Inoue, Moe, Okuda, Atsuhiro, Yasuhara, Jurika, Murakami, Calvin, Duong, Kiyoko, Iwatsuki-Horimoto, Seiya, Yamayoshi, and Yoshihiro, Kawaoka
- Subjects
Adult ,Immunoglobulin M ,Japan ,SARS-CoV-2 ,Immunoglobulin G ,Internal Medicine ,COVID-19 ,Humans ,General Medicine ,Antibodies, Viral ,Hematologic Diseases ,Retrospective Studies - Abstract
Objective Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread globally. Although the relationship between anti-SARS-CoV-2 immunoglobulin G (IgG) antibodies and COVID-19 severity has been reported, information is lacking regarding the seropositivity of patients with particular types of diseases, including hematological diseases. Methods In this single-center, retrospective study, we compared SARS-CoV-2 IgG positivity between patients with hematological diseases and those with non-hematological diseases. Results In total, 77 adult COVID-19 patients were enrolled. Of these, 30 had hematological disorders, and 47 had non-hematological disorders. The IgG antibody against the receptor-binding domain of the spike protein was detected less frequently in patients with hematological diseases (60.0%) than in those with non-hematological diseases (91.5%; p=0.029). Rituximab use was significantly associated with seronegativity (p=0.010). Conclusion Patients with hematological diseases are less likely to develop anti-SARS-CoV-2 antibodies than those with non-hematological diseases, which may explain the poor outcomes of COVID-19 patients in this high-risk group.
- Published
- 2022