1. Effects of Efonidipine Hydrochloride on Renal Arteriolar Diameters in Spontaneously Hypertensive Rats
- Author
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Masuhisa Nakamura, Yuka Kohda, Yuko Takashita, Mitsuru Notoya, Munekazu Gemba, and Junji Yamashita
- Subjects
Male ,Efferent arteriole ,Dihydropyridines ,medicine.medical_specialty ,Hypertension, Renal ,Physiology ,Efferent ,Kidney Glomerulus ,Hydrostatic pressure ,Lumen (anatomy) ,Blood Pressure ,Efonidipine ,Corrosion Casting ,Renal Circulation ,Nitrophenols ,Organophosphorus Compounds ,Rats, Inbred SHR ,Internal medicine ,Internal Medicine ,medicine ,Animals ,Renal circulation ,Chemistry ,Body Weight ,Lisinopril ,Calcium Channel Blockers ,Rats ,Arterioles ,Endocrinology ,medicine.anatomical_structure ,Blood pressure ,Cardiology and Cardiovascular Medicine ,circulatory and respiratory physiology ,medicine.drug - Abstract
Efonidipine, a calcium antagonist, has been reported to dilate not only afferent but also efferent arterioles, thereby reducing glomerular hydrostatic pressure. We investigated the effect of chronic treatment with efonidipine or lisinopril on the afferent and efferent arteriolar diameters by the vascular cast technique. Four-week-old spontaneously hypertensive rats (SHR) were divided into three groups: untreated, efonidipine (25 mg/kg/day)-treated, and lisinopril (3 mg/kg/day)-treated. At 22 weeks of age, the renal vasculatures were fixed at the maximally dilated condition. The morphometrical measurements showed that the treatments with efonidipine and lisinopril caused structural alteration of the vasculature, resulting in significantly greater efferent arteriolar diameters than in untreated SHR. In addition, lisinopril-treated rats had wider afferent lumina. The renoprotective effect of efonidipine and lisinopril might be partly due to the structurally larger efferent arteriolar lumen.
- Published
- 2002
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