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Your search keyword '"Inoue, Ryuji"' showing total 19 results
Start Over Author "Inoue, Ryuji" Publisher japanese pharmacological society
19 results on '"Inoue, Ryuji"'

4. TRPC5 channel-Caveolin-1-eNOS signalplexes coordinate interplay between Ca2+ and NO signals in endothelial cells

Author

Sakaguchi, Reiko, primary, Takahashi, Nobuaki, additional, Yoshida, Takashi, additional, Ogawa, Nozomi, additional, Ueda, Yoshifumi, additional, Hamano, Satoshi, additional, Yamaguchi, Kaori, additional, Sawamura, Seishiro, additional, Yamamoto, Shinichiro, additional, Hara, Yuji, additional, Mori, Masayuki, additional, Furukawa, Tetsushi, additional, Shimizu, Shunichi, additional, Inoue, Ryuji, additional, and Mori, Yasuo, additional

Published
2021
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11. Dual Signaling Pathways of Arterial Constriction by Extracellular Uridine 5′-Triphosphate in the Rat

Author

Sugihara, Megumi, primary, Morita, Hiromitsu, additional, Matsuda, Miho, additional, Umebayashi, Hisanori, additional, Kajioka, Shunichi, additional, Ito, Shinichi, additional, Nishida, Motohiro, additional, Inoue, Ryosuke, additional, Futatsuki, Toshiko, additional, Yamazaki, Jun, additional, Mori, Yasuo, additional, Inoue, Ryuji, additional, Ito, Yushi, additional, Abe, Kihachiro, additional, and Hirata, Masato, additional

Published
2011
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19. Possible involvement of M5 muscarinic receptor in the enhancing actions of the novel gastroprokinetic agent Z-338 on nifedipine-sensitive voltage-dependent Ca2+ currents in guinea pig stomach.

Author

Morita H, Abe K, Ito Y, and Inoue R

Subjects
Animals, Calcium Channel Blockers pharmacology, Dose-Response Relationship, Drug, Drug Synergism, Female, Guinea Pigs, Male, Membrane Potentials drug effects, Membrane Potentials physiology, Receptor, Muscarinic M5, Stomach physiology, Benzamides pharmacology, Calcium Channels, L-Type physiology, Gastrointestinal Agents pharmacology, Nifedipine pharmacology, Receptors, Muscarinic physiology, Stomach drug effects, Thiazoles pharmacology
Abstract

We investigated the effects of the novel gastroprokinetic agent Z-338 (N-(N-N'-diisopropylaminoethyl)-[2-(2-hydroxy-4,5-dimethoxybenzoylamino)-1,3-thiazole-4-yl] carboxyamide monohydrochloride trihydrate) on L-type voltage-dependent Ca2+ currents (ICa) in guinea pig gastric myocytes by using the whole-cell patch clamp technique. Bath-applied acetylcholine (ACh) produced biphasic effects on ICa, i.e., enhancement (1-100 nM) and inhibition (1-100 microM), both of which were abolished by pretreatment with atropine (10 microM) or intracellular perfusion of GDPbetaS (500 microM). Z-338 (> or = 1 nM, ED50: 120 nM) mimicked the enhancing effects of ACh, but did not inhibit ICa. The effects of Z-338 and ACh were non-additive and blocked by atropine and GDPbetaS, but not by pertussis toxin (PTX) pretreatment (500 ng/ml). ACh (> or = 1 microM) induced slow inward currents via activation of the muscarinic receptor/PTX-sensitive G-protein pathway, but Z-338 was devoid of these effects. Neither pirenzepine (1 microM), AF-DX116 (1 microM), nor oxybutynin (100 nM) could prevent Z-338 (1 microM) and ACh (10 nM) from enhancing ICa, whilst 4-DAMP (100 nM) blocked the effects of Z-338 and ACh. Bath-application of protein kinase C (PKC) activator PDBu (phorbol-12,13-dibutyrate) (250 nM) enhanced ICa, and conversely, pipette inclusion of PKC inhibitor peptide (150 microM) abolished the effects of ACh and Z-338 on ICa. These results collectively suggest that although contribution of the M3 receptor is not excluded, the major actions of Z-338 on gastric myocytes are potentiation of ICa through activation of M5-like receptor.

Published
2002
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