1. Delivery of Curcumin Using Skim Milk or Oil in Water Emulsions: Effect of the Matrices on Cellular Uptake
- Author
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Elena Arranz, İbrahim Gülseren, Anilda Guri, and Milena Corredig
- Subjects
skim milk powders ,0301 basic medicine ,Curcumin ,food.ingredient ,General Chemical Engineering ,curcumin encapsulation ,Oil in water ,03 medical and health sciences ,chemistry.chemical_compound ,0404 agricultural biotechnology ,food ,Functional Food ,Skimmed milk ,Animals ,Humans ,spray drying ,Food science ,Powder mixture ,Spray dried ,030109 nutrition & dietetics ,Chemistry ,Water ,cellular uptake ,food and beverages ,Food grade ,Caco-2 ,04 agricultural and veterinary sciences ,General Medicine ,General Chemistry ,040401 food science ,Extracellular Matrix ,Milk ,Spray drying ,Emulsion ,Emulsions ,Caco-2 Cells ,Powders ,Oils - Abstract
2nd Asian Conference on Oleo Science (ACOS) / 56th Annual Meeting of the Japan-Oil-Chemists'-Society (JOCS) -- SEP 11-13, 2017 -- Tokyo Univ Sci, Kagurazaka Campus, Tokyo, JAPAN WOS: 000451293900002 PubMed ID: 29760329 To enhance the curcumin delivery in a variety of food grade matrices namely spray dried ethanolic curcumin in fresh skim milk (Spray dried Cu-SM), a fresh mixture of ethanolic curcumin and skim milk (Fresh Cu-SM) a powder mixture of curcumin and skim milk powder (Powder Cu-SMP) and oil in water emulsion (Emulsion) were studied. The cellular uptake of curcumin from the respective matrices was studied on Caco-2 cell monolayers. Spray dried Cu-SM showed higher encapsulation efficiency compared to a corresponding Powder Cu-SMP and an oil-in-water emulsion (40% oil) bearing curcumin. Furthermore, ethanolic administration of curcumin in spray dried form enhanced the cellular uptake of curcumin considerably higher than non-ethanolic samples (approx. 4 times). Overall, milk protein based vectors were found to perform better than emulsion samples. These findings highlighted the fact that curcumin uptake may be tailored by fine tuning of curcumin delivery vehicles which highlights possible application of powders as functional foods. Japan Oil Chemists Soc
- Published
- 2018