1. Diagnosis of central diabetes insipidus using a vasopressin radioimmunoassay during hypertonic saline infusion
- Author
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Yoshihiro Ito, Hidetaka Suga, Shigeyuki Matsui, Ryoichi Banno, Kunihiko Takahashi, Takeshi Onoue, Hiroshi Takagi, Mariko Sugiyama, Taku Tsunekawa, Motomitsu Goto, Daisuke Hagiwara, Tomoko Handa, Hiroshi Arima, and Shintaro Iwama
- Subjects
Male ,endocrine system ,Vasopressin ,medicine.medical_specialty ,genetic structures ,Vasopressins ,Endocrinology, Diabetes and Metabolism ,Radioimmunoassay ,Urology ,030209 endocrinology & metabolism ,Urine ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Polyuria ,medicine ,Humans ,Primary polydipsia ,Saline Solution, Hypertonic ,business.industry ,Sodium ,Middle Aged ,medicine.disease ,Hypertonic saline ,Arginine Vasopressin ,Diabetes Insipidus, Neurogenic ,030220 oncology & carcinogenesis ,Diabetes insipidus ,Female ,medicine.symptom ,business ,Polydipsia ,hormones, hormone substitutes, and hormone antagonists - Abstract
Central diabetes insipidus (CDI) is characterized by polyuria and polydipsia caused by impairment of arginine vasopressin (AVP) secretion. In this study, we evaluated plasma AVP concentrations during a hypertonic saline infusion test using a new AVP radioimmunoassay (RIA) which is now available in Japan. Thirteen control subjects, mostly with hypothalamo-pituitary disease but without CDI, and 13 patients with CDI were enrolled in the study. Whether or not subjects had CDI was determined based on the totality of clinical data, which included urine volumes and osmolality. Regression analysis of plasma AVP and serum Na concentrations revealed that the gradient was significantly lower in the CDI group than in the control group. The area under the receiver-operating-characteristic (ROC) curve was 0.99, and the
- Published
- 2020
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