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Start Over Author "Shigeki Yabe" Publisher japan endocrine society
3 results on '"Shigeki Yabe"'

1. Association of Antipituitary Antibody and Type 2 Iodothyronine Deiodinase Antibody in Patients with Autoimmune Thyroid Disease

Author

Katsuhiko Tsunekawa, Isao Kobayashi, Takayuki Kasahara, M Nara, Masami Murakami, Koji Seki, Shigeki Yabe, Michio Nishino, Takayuki Ogiwara, and Rieko Nakahara

Subjects
Adult, Male, endocrine system, Pituitary gland, medicine.medical_specialty, Adolescent, endocrine system diseases, Hashimoto's disease, Endocrinology, Diabetes and Metabolism, Graves' disease, education, Thyroid Gland, Enzyme-Linked Immunosorbent Assay, Hashimoto Disease, Iodide Peroxidase, Endocrinology, Antigen, Internal medicine, mental disorders, medicine, Humans, Immunoprecipitation, Child, Aged, Autoantibodies, Aged, 80 and over, biology, business.industry, Thyroid, Case-control study, Middle Aged, medicine.disease, Graves Disease, medicine.anatomical_structure, Case-Control Studies, Pituitary Gland, Iodothyronine deiodinase, Immunology, biology.protein, Female, Antibody, business, psychological phenomena and processes
Abstract

Antipituitary antibody (APA) has been reported to be detected in patients with autoimmune thyroid disease. Type 2 iodothyronine deiodinase (D2) is expressed in both pituitary gland and thyroid gland. We studied the association of APA and D2 peptide antibody in patients with autoimmune thyroid disease. Rat pituitary gland homogenate and D2 peptide were used as antigens in the present study. APA and D2 peptide antibodies were measured by enzyme-linked immunosorbent assay (ELISA) in sera obtained from 42 patients with Hashimoto's disease, 26 patients with Graves' disease and 70 healthy control subjects. Moreover, D2 activity precipitation assay was performed in some patients with Hashimoto's disease. APA and D2 peptide antibody were elevated in patients with Hashimoto's disease and patients with Graves' disease, compared with control subjects. APA was positive in 32.4% (22/68), D2 peptide antibody was positive in 26.5% (18/68) of patients with autoimmune thyroid disease. APA was positive in 31.0% (13/42) of patients with Hashimoto's disease and 34.6% (9/26) of patients with Graves' disease. D2 peptide antibody was positive in 26.2% (11/42) of patients with Hashimoto's disease and 26.9% (7/26) of patients with Graves' disease. D2 peptide antibody was correlated with APA in patients with autoimmune thyroid disease. Moreover, precipitation of D2 activity was increased in some patients with Hashimoto's disease including a patient who also had idiopathic diabetes insipidus, and was correlated with D2 peptide antibody. These results suggest that D2 antibody may be associated with APA in patients with autoimmune thyroid disease.

Published
2005
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2. Antipituitary Antibodies as Pathogenetic Factors in Patients with Pituitary Disorders

Author

Takashi Kikuchi, Shigeki Yabe, Tsugiyasu Kanda, and Isao Kobayashi

Subjects
Adult, Male, medicine.medical_specialty, Time Factors, Pituitary disorder, Adolescent, Pituitary Diseases, Endocrinology, Diabetes and Metabolism, Immunoblotting, education, Enzyme-Linked Immunosorbent Assay, Antibodies, Growth hormone deficiency, Levodopa, Pathogenesis, Endocrinology, Japan, Antigen, Immunoblot Analysis, Internal medicine, Acromegaly, medicine, Humans, Endocrine system, Pituitary Neoplasms, Lymphocyte Count, Child, Pathological, business.industry, Middle Aged, medicine.disease, Child, Preschool, Growth Hormone, Pituitary Gland, Female, business
Abstract

Our previous reports showed detection of antipituitary antibodies (APA) by immunoblot analysis and enzyme linked immunosorbent assay (ELISA) by using rat pituitary tissue as antigen in patients with certain endocrine disorders. In the present report, we evaluated APA by using our immunoblot and ELISA technique in 76 patients with various pituitary disorders. The prevalence of a 22 kDa band of APA detected by immunoblot was found to be significantly higher (P

Published
2000
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3. A Case of Autoimmune Hypophysitis Associated with Asymptomatic Primary Biliary Cirrhosis

Author

Kunio Koshimura, Yoshio Murakami, Masateru Nishiki, Motoi Sohmiya, Shigeki Yabe, Isao Kobayashi, Yuzuru Kato, and Junko Tanaka

Subjects
Male, Pathology, medicine.medical_specialty, Pituitary gland, Endocrinology, Diabetes and Metabolism, Hypopituitarism, Asymptomatic, Antibodies, Autoimmune Diseases, Endocrinology, Primary biliary cirrhosis, Anterior pituitary, medicine, Humans, medicine.diagnostic_test, Liver Cirrhosis, Biliary, business.industry, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Mitochondria, medicine.anatomical_structure, Liver, Pituitary Gland, Liver biopsy, Immunology, Autoimmune hypophysitis, medicine.symptom, business, Anti-mitochondrial antibody
Abstract

We report a 61-year old male patient with panhypopituitarism complicated with asymptomatic primary biliary cirrhosis (PBC). T1-weighted magnetic resonance imaging demonstrated high intensity of the anterior pituitary gland. There was no mass lesion or enlargement of the pituitary gland or the stalk. Immunoblot analysis of the patient's sera with rat pituitary antigens revealed a band with a molecular size of 22 kD. Anti-M2 mitochondrial antibody has been consistently positive for five years. Liver biopsy revealed portal hepatitis with periportal infiltration of the inflammatory cells. This is the first case report of autoimmune hypophysitis complicated with asymptomatic PBC.

Published
1998
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