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Your search keyword '"Sohda, H"' showing total 2 results
Start Over Author "Sohda, H" Publisher japan antibiotics research assn
2 results on '"Sohda, H"'

1. [Clinical evaluation of cefixime in children].

Author

Meguro H, Arimasu O, Sohda H, Yoshida J, Togasaki K, and Fujii R

Subjects
Cefixime, Cefotaxime metabolism, Cefotaxime pharmacology, Cefotaxime therapeutic use, Child, Child, Preschool, Female, Haemophilus Infections drug therapy, Humans, Infant, Kinetics, Male, Pneumonia drug therapy, Pneumonia, Mycoplasma drug therapy, Bacterial Infections drug therapy, Cefotaxime analogs & derivatives, Respiratory Tract Infections drug therapy, Urinary Tract Infections drug therapy
Abstract

A new beta-lactamase-stable oral cephem antibiotic, cefixime (CFIX), was evaluated for safety, efficacy and pharmacokinetics in children. CFIX was effective in 19 of 20 cases (95%) with bacterial infections. The drug was especially effective against the cases of pneumonia due to beta-lactamase-producing H. influenzae or B. catarrhalis. Pharmacokinetic parameters of CFIX (3 mg/kg) with premeal administration were as follows: Kel 0.328 +/- 0.066 hr-1, T 1/2 2.14 +/- 0.36 hrs, AUC 10.9 +/- 8.7 micrograms X hr/ml, and Vd/F 1.64 +/- 1.42 L/kg. In most of the cases tested, the urinary excretion rate in 12 hours was 5 to 17%. A dose of 3 mg/kg twice daily seems to be adequate for a regular treatment.

Published
1986

2. [Clinical and pharmacokinetic evaluations of aztreonam in children].

Author

Meguro H, Arimasu O, Sugamata K, Hiruma F, Sohda H, Shiraishi H, and Fujii R

Subjects
Age Factors, Aztreonam metabolism, Bacterial Infections microbiology, Child, Child, Preschool, Drug Evaluation, Female, Humans, Infant, Kinetics, Male, Aztreonam therapeutic use, Bacterial Infections drug therapy
Abstract

Aztreonam (AZT) was evaluated for its safety, clinical efficacy and pharmacokinetics in children. AZT was effective in all the 16 children with Gram-negative bacterial infections. The diagnoses included acute bronchitis and pneumonia (11), UTI (2), UTI with bacteremia (1), purulent meningitis (1) and acute mucositis (1). The etiologic agents were H. influenzae (10), B. catarrhalis (1), N. meningitidis group C (1), E. coli (3) and P. aeruginosa (2). The serum half-life was approximately 1.2 hours after intravenous bolus injection. Penetration into the inflamed cerebrospinal fluid was good not only in acute purulent meningitis but also in viral meningitis. From the present study, AZT is a safe and effective antibiotic when used in children with Gram-negative bacterial infections.

Published
1985

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