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Your search keyword '"Pancreatic cancer -- Patient outcomes"' showing total 27 results
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27 results on '"Pancreatic cancer -- Patient outcomes"'

1. Molecular predictors of outcome in a phase 3 study of gemcitabine and erlotinib therapy in patients with advanced pancreatic cancer: National Cancer Institute of Canada Clinical Trials Group Study PA.3

Author

da Cunha-Santos, Gilda, Dhani, Neesha, Tu, Dongsheng, Chin, Kayu, Ludkovski, Olga, kamel-Reid, Suzanne, Squire, Jeremy, Parulekar, Wendy, Moore, Malcolm J., and Tsao, Ming Sound

Subjects
Pancreatic cancer -- Care and treatment, Pancreatic cancer -- Patient outcomes, Pancreatic cancer -- Research, Gemcitabine -- Dosage and administration, Gemcitabine -- Complications and side effects, Gemcitabine -- Research, Erlotinib -- Dosage and administration, Erlotinib -- Complications and side effects, Erlotinib -- Research, Health
Published
2010

2. Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer

Author

Tanaka, Motofumi, Javle, Milind, Dong, Xiaoqun, Eng, Cathy, Abbruzzese, James L., and Li, Donghui

Subjects
Pancreatic cancer -- Drug therapy, Pancreatic cancer -- Patient outcomes, Pancreatic cancer -- Diagnosis, Genetic polymorphisms -- Research, Genetic polymorphisms -- Physiological aspects, Gemcitabine -- Usage, Gemcitabine -- Health aspects, Drugs -- Health aspects, Drugs -- Research, Drugs -- Risk factors, Health
Published
2010

3. Expression of p16INK4A but not hypoxia markers or poly adenosine diphosphate-ribose polymerase is associated with improved survival in patients with pancreatic adenocarcinoma

Author

Chang, Daniel T., Chapman, Christopher H., Norton, Jeffrey A., Visser, Brendan, Fisher, George A., Kunz, Pamela, Ford, James M., Koong, Albert C., and Pai, Reetesh K.

Subjects
Pancreatic cancer -- Genetic aspects, Pancreatic cancer -- Patient outcomes, Gene mutations -- Research, Gene mutations -- Physiological aspects, Adenosine diphosphate -- Research, Adenosine diphosphate -- Physiological aspects, Polymerase chain reaction -- Research, Polymerase chain reaction -- Physiological aspects, Health
Published
2010

4. Obesity adversely affects survival in pancreatic cancer patients

Author

McWilliams, Robert R., Matsumoto, Martha E., Burch, Patrick A., Kim, George P., Halfdanarson, Thorvardur R., de Andrade, Mariza, Reid-Lombardo, Kaye, and Bamlet, William R.

Subjects
Pancreatic cancer -- Patient outcomes, Pancreatic cancer -- Demographic aspects, Pancreatic cancer -- Research, Obesity -- Influence, Obesity -- Research, Cancer patients -- Prognosis, Cancer patients -- Research, Health
Published
2010

6. A national propensity-adjusted analysis of adjuvant radiotherapy in the treatment of resected pancreatic adenocarcinoma

Author

McDade, Theodore P., Hill, Joshua S., SImons, Jessica P., Piperdi, Bilal, Ng, Sing Chau, Zhou, Zheng, Kadish, Sidney P., Fitzgerald, Thomas J., and Tseng, Jennifer F.

Subjects
Pancreatic cancer -- Care and treatment, Pancreatic cancer -- Patient outcomes, Pancreatic cancer -- Research, Radiotherapy -- Patient outcomes, Radiotherapy -- Research, Propensity scores -- Analysis, Health
Published
2010

7. Adjuvant therapy and survival after resection of pancreatic adenocarcinoma: a population-based analysis

Author

Mayo, Skye C., Austin, Donald F., Sheppard, Brett C., Mori, Motomi, Shipley, Donald K., and Billingsley, Kevin G.

Subjects
Pancreatic cancer -- Care and treatment, Pancreatic cancer -- Patient outcomes, Pancreatic cancer -- Research, Adenocarcinoma -- Care and treatment, Adenocarcinoma -- Patient outcomes, Adenocarcinoma -- Research, Pancreatectomy -- Patient outcomes, Pancreatectomy -- Research, Cancer -- Adjuvant treatment, Cancer -- Patient outcomes, Cancer -- Research, Health
Published
2010

8. Progress for resectable cancer? A population-based assessment of US practices

Author

Simons, Jessica P., Ng, Sing Chau, McDade, Theodore P., Zhou, Zheng, Earle, Craig C., and Tseng, Jennifer F.

Subjects
Pancreatic cancer -- Care and treatment, Pancreatic cancer -- Patient outcomes, Pancreatic cancer -- Research, Chemotherapy -- Patient outcomes, Chemotherapy -- Research, Cancer -- Chemotherapy, Cancer -- Patient outcomes, Cancer -- Research, Health
Published
2010

9. Quality of life after adjuvant intra-arterial chemotherapy and radiotherapy versus surgery alone in resectable pancreatic and periampullary cancer: a prospective randomized controlled study

Author

Morak, Marjolein J.M., Pek, Chulja J., Kompanje, Erwin J.O., Hop, Wim C.J., Kazemier, Geert, and van Eijck, Casper H.J.

Subjects
Pancreatic cancer -- Care and treatment, Pancreatic cancer -- Patient outcomes, Pancreatic cancer -- Research, Radiotherapy -- Patient outcomes, Radiotherapy -- Research, Quality of life -- Health aspects, Quality of life -- Research, Cancer -- Adjuvant treatment, Cancer -- Patient outcomes, Cancer -- Research, Health
Published
2010

10. Are patients of low socioeconomic status receiving suboptimal management for pancreatic adenocarcinoma?

Author

Cheung, Michael C., Yang, Relin, Byrne, Margaret M., Solorzano, Carmen C., Nakeeb, Attila, and Koniairs, Leonidas G.

Subjects
Pancreatic cancer -- Care and treatment, Pancreatic cancer -- Patient outcomes, Pancreatic cancer -- Demographic aspects, Pancreatic cancer -- Research, Adenocarcinoma -- Care and treatment, Adenocarcinoma -- Patient outcomes, Adenocarcinoma -- Demographic aspects, Adenocarcinoma -- Research, Social classes -- Health aspects, Social classes -- Research, Health
Published
2010

11. Pilot study of huachansu in patients with hepatocellular carcinoma, nonsmall-cell lung cancer, or pancreatic cancer

Author

Meng, Zhiqiang, Yang, Peiying, Shen, Yehua, Bel, Wenying, Zhang, Ying, Ge, Yongqian, Newman, Robert A., Cohen, Lorenzo, Liu, Luming, Thornton, Bob, Chang, David Z., Liao, Zongxing, and Kurzrock, Razelle

Subjects
Lung cancer, Non-small cell -- Care and treatment, Lung cancer, Non-small cell -- Research, Lung cancer, Non-small cell -- Patient outcomes, Medicine, Chinese -- Usage, Medicine, Chinese -- Research, Pancreatic cancer -- Care and treatment, Pancreatic cancer -- Patient outcomes, Pancreatic cancer -- Research, Health
Published
2009

12. Results and patterns of failure in patients treated with adjuvant combined chemoradiation therapy for resected pancreatic adenocarcinoma

Author

Hattangadi, Jona A., Hong, Theodore S., Yeap, Beow Y., and Mamon, Harvey J.

Subjects
Pancreatic cancer -- Care and treatment, Pancreatic cancer -- Patient outcomes, Pancreatic cancer -- Research, Outcome and process assessment (Health Care) -- Research, Gemcitabine -- Dosage and administration, Gemcitabine -- Research, Chemotherapy -- Patient outcomes, Chemotherapy -- Research, Radiotherapy -- Patient outcomes, Radiotherapy -- Research, Cancer -- Chemotherapy, Cancer -- Patient outcomes, Cancer -- Research, Health
Published
2009

13. Carbohydrate antigen 19-9 change during chemotherapy for advanced pancreatic adenocarcinoma

Author

Reni, Michele, Cereda, Stefano, Balzano, Gianpaolo, Passoni, Paolo, Rognone, Alessia, Fugazza, Clara, Mazza, Elena, Zerbi, Alessandro, Di Carlo, Valerio, and Villa, Eugenio

Subjects
Pancreatic cancer -- Care and treatment, Pancreatic cancer -- Development and progression, Pancreatic cancer -- Patient outcomes, Pancreatic cancer -- Research, Chemotherapy -- Patient outcomes, Chemotherapy -- Research, Tumor antigens -- Research, Adenocarcinoma -- Development and progression, Adenocarcinoma -- Care and treatment, Adenocarcinoma -- Patient outcomes, Adenocarcinoma -- Research, Cancer -- Chemotherapy, Cancer -- Patient outcomes, Cancer -- Research, Health
Published
2009

15. Stereotactic radiotherapy for unresectable adenocarcinoma of the pancreas

Author

Chang, Daniel T., Schellenberg, Devin, Shen, John, Kim, Jeff, Goodman, Karyn A., Fisher, George A., Ford, James M., Desser, Terry, Quon, Andrew, and Koong, Albert C.

Subjects
Adenocarcinoma -- Care and treatment, Adenocarcinoma -- Patient outcomes, Adenocarcinoma -- Research, Pancreatic cancer -- Care and treatment, Pancreatic cancer -- Patient outcomes, Pancreatic cancer -- Research, Radiosurgery -- Patient outcomes, Radiosurgery -- Research, Health
Published
2009

17. Improved survival with adjuvant external-beam radiation therapy in lymph node-negative pancreatic cancer: a United States population-based assessment

Author

Artinyan, Avo, Hellan, Minia, Mojica-Manosa, Pablo, Chen, Yi-Jen, Pezner, Richard, Ellenhorn, Joshua D.I., and Kim, Joseph

Subjects
Pancreatic cancer -- Care and treatment, Pancreatic cancer -- Patient outcomes, Pancreatic cancer -- Research, Radiotherapy -- Methods, Radiotherapy -- Patient outcomes, Radiotherapy -- Research, Lymph nodes -- Physiological aspects, Health
Published
2008

18. Is resection of periampullary or pancreatic adenocarcinoma with synchronous hepatic metastasis justified?

Author

Gleisner, Ana Luiza, Assumpcao, Lia, Cameron, John L., Wolfgang, Christopher L., Choti, Michael A., Herman, Joseph M., Schulick, Richard D., and Pawlik, Timothy M.

Subjects
Adenocarcinoma -- Care and treatment, Adenocarcinoma -- Patient outcomes, Pancreatic cancer -- Care and treatment, Pancreatic cancer -- Patient outcomes, Metastasis -- Research, Pancreatectomy -- Patient outcomes, Ampulla of Vater -- Diseases, Health
Published
2007

19. Radiation therapy is associated with improved survival in patients with pancreatic adenocarcinoma: results of a study from the Surveillance, Epidemiology, and End Results (SEER) Registry Data

Author

Hazard, Lisa, Tward, Jonathan D., Szabo, Aniko, and Shrieve, Dennis C.

Subjects
Pancreatic cancer -- Care and treatment, Pancreatic cancer -- Patient outcomes, Pancreatic cancer -- Surveys, Radiotherapy -- Usage, Oncology, Experimental -- Reports, Cancer -- Research, Cancer -- Reports, Health
Published
2007

21. Validation of the 6th edition AJCC pancreatic cancer staging system: report from the National Cancer Database

Author

Bilimoria, Karl Y., Bentrem, David J., Ko, Clifford Y., Ritchey, Jamie, Stewart, Andrew K., Winchester, David P., and Talamonti, Mark S.

Subjects
Pancreatic cancer -- Patient outcomes, Pancreatic cancer -- Diagnosis, Pancreatic cancer -- Research, Pancreatectomy -- Patient outcomes, Tumor staging -- Standards, Tumor staging -- Methods, Health, American Joint Committee on Cancer -- Standards, American College of Surgeons -- Reports
Published
2007

22. Aberrant methylation of reprimo correlates with genetic instability and predicts poor prognosis in pancreatic ductal adenocarcinoma

Author

Sato, Norihiro, Fukushima, Noriyoshi, Matsubayashi, Hiroyuki, Iacobuzio-Donahue, Christine A., Yeo, Charles J., and Goggins, Michael

Subjects
Pancreatic cancer -- Development and progression, Pancreatic cancer -- Patient outcomes, Pancreatic cancer -- Genetic aspects, Carcinoma, Ductal -- Development and progression, Carcinoma, Ductal -- Patient outcomes, Carcinoma, Ductal -- Genetic aspects, Methylation -- Research, Oncogenes -- Research, Cancer patients -- Prognosis, Health
Published
2006

24. Intraoperative and conformal external-beam radiation therapy with protracted 5-fluorouracil infusion in patients with locally advanced pancreatic carcinoma

Author

Furuse, Junji, Kinoshita, Taira, Kawashima, Mitsuhiko, Ishii, Hiroshi, Nagase, Michitaka, Konishi, Masaru, Nakagohri, Toshio, Inoue, Kazuto, Ogino, Takashi, Ikeda, Hiroshi, Maru, Yasushi, and Yoshino, Masahiro

Subjects
Radiotherapy -- Methods, Radiotherapy -- Evaluation, Pancreatic cancer -- Care and treatment, Pancreatic cancer -- Drug therapy, Pancreatic cancer -- Patient outcomes, Fluorouracil -- Dosage and administration, Fluorouracil -- Evaluation, Health
Published
2003

25. Prognostic factors for survival after pancreaticoduodenectomy for patients with carcinoma of the pancreatic head region

Author

Allema, J. Hein, Reinders, Marcel E., Gulik, Thomas M. van, Koelemay, Mark J.W., Leeuwen, Dirk J. Van, Wit, Laurens Th. de, Gouma, Dirk J., and Obertop, Huug

Subjects
Pancreatic cancer -- Patient outcomes, Pancreatectomy -- Evaluation, Health
Abstract

Background. The aim of this study was to determine prognostic factors for survival after pancreaticoduodenectomy (PD) for carcinoma of the pancreatic head region. Methods. From 1983 to 1992.176 patients underwent PD for ampullary carcinoma (n = 67), distal bile duct carcinoma (n = 42), or pancreatic carcinoma (n = 67). The first choice for resection was subtotal PD (n 146), but patients with a tumor-positive pancreatic margin or a brittle pancreatic duct underwent total PD (n = 30). Results. Hospital mortality was 4.7% after subtotal PD and 20% after total PD. Overall 5-year survival was 31%. Survival after PD for ampullary carcinoma care. (5-year, 50%) was significantly better (P < 0.001) than for distal bile duct carcinoma (24%) and pancreatic carcinoma (14%). Independent negative prognostic factors for survival (multivariate analysis) were involved resection margins (hazard rate ratio [HRR] 4.08), major vascular involvement IRR 2.20), distal bile duct or pancreatic origin of carcinoma (HRR 1.93), and perioperative blood transfusion of more than 4 U (HRR 1.76). Tumor size ( >2 cm), regional lymph node involvement, and a poor differentiation grade were overall negative factors in univariate analysis but not in the subgroup of ampullary carcinoma. Conclusion. Involvement of resection margins, major vascular ingrowth, site of origin of carcinoma, and perioperative blood transfusion were independent prognostic factors for survival after PD. Overall 5-year survival was 31%, and subtotal PD is advocated for all patients with a macroscopically resectable tumor in the pancreatic head region without major vascular involvement, even for those with larger tumors or local lymph node metastasis. Care should be taken to limit the need for perioperative blood transfusions. Cancer 1995; 75:2069-76. Key words: pancreaticoduodenectomy, prognostic factors, survival, pancreatic carcinoma, distal bile duct carcinoma, ampullary carcinoma.

Published
1995

26. Acute-phase protein response and survival duration of patients with pancreatic cancer

Author

Falconer, J. Stuart, Fearon, Kenneth C.H., Ross, James A., Elton, Robert, Wigmore, Stephen J., Garden, O. James, and Carter, David C.

Subjects
Pancreatic cancer -- Patient outcomes, C-reactive protein, Protein metabolism -- Physiological aspects, Weight loss -- Health aspects, Health
Abstract

Background Current methods to predict survival duration of patients with pancreatic cancer are limited. The aim of this study was to determine whether certain nutritional indices and the acute-phase protein response are prognostic factors independent of disease stage for patients with unresectable pancreatic cancer. Methods. Variables at the time of diagnosis of 102 patients with unresectable pancreatic cancer were entered into a Cox's proportional hazards model. Included in the analysis were the serum concentration of C-reactive protein (CRP) and albumin, the extent of weight loss, age, sex, and disease stage (International Union Against Cancer criteria). Results. A multivariate analysis in which each factor was adjusted for the influence of the other factors revealed the patient age, disease stage, serum albumin, and serum CRP to be independent predictors of survival. The presence of an acute-phase protein response was the most significant independent predictor of survival duration. The median survival of those with an acute-phase protein response (CRP > 10 mg/L, n = 45) was 66 days compared with 222 days for those with no acute-phase protein response (n = 57, P = 0.001, Mann-Whitney U test). Conclusion. The acute-phase protein response is a useful prognostic indicator for patients with unresectable pancreatic cancer. Moreover, the metabolic disturbances associated with an acute-phase protein response of patients with pancreatic cancer may be a worthwhile therapeutic target. Cancer 1995; 75:2077-82. Key words: acute-phase protein response, prognostic factors, survival, pancreatic cancer.

Published
1995

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