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Your search keyword '"Khovanskikh AE"' showing total 2 results
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2 results on '"Khovanskikh AE"'

1. [Selective N-heterylazimine inhibition of reactions catalyzed by rat liver glutathione transferase].

Author

Stulovskiĭ AV, Voznyĭ IV, Rozengart EV, Suvorov AA, and Khovanskikh AE

Subjects
Animals, Catalysis, Molecular Structure, Oxygen metabolism, Rats, Rats, Wistar, Sulfhydryl Compounds metabolism, Glutathione Transferase antagonists & inhibitors, Liver enzymology
Abstract

Three reactions (nucleophile substitution, thiolysis and N-deoxygenation) catalyzed by rat liver glutathione transferase have been studied using several N-heterylazimine inhibitors. The inhibitors are sharply different in their effectiveness in the transferase reactions. Their efficiency depends on their structure. The mechanism which underlies the found regularities is suggested.

Published
1992

2. [Interaction of the rat liver glutathione transferase system with 1-phthalimidoazimines].

Author

Stulovskiĭ AV, Suvorov AA, Maĭzel' EB, Rozengart EV, and Khovanskikh AE

Subjects
Animals, Glutathione metabolism, Rats, Glutathione Transferase metabolism, Liver enzymology, Phthalimides metabolism
Abstract

The interaction of rat liver glutathione and glutathione transferase with several 1-phthalimidoazimines is studied. Differences between spontaneous and enzymatic reactions of azimines and reduced glutathione are shown. It is pointed out that the formation of glutathione-azimine complexes takes place in the reaction mixture.

Published
1991

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