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The study included 96 women with combined benign hyperplastic uterine conditions. Half of them underwent a radical uterine resection and were examined at 3.1 +/- 0.2 years following the operation. The rest were randomly selected as matched pairs and were evaluated at 4.3 +/- 0.13 years following multicomponent treatment including hormones (n-26) and cryohormonal treatment (n-22). Analysis of results revealed a complex pathogenesis of this disease of the reproductive tract, presenting as severe postoperative vegetoneurotic disorders. Potential of an adequate conservative treatment in preserving specific female functions was determined.

The definition of concomitant benign hyperplastic diseases of the uterus relates to the abnormalities of the female reproductive system which are accompanied with a simultaneous development of uterine hyperplasias or endometrial polyps, myomas and/or endometriosis. The investigation of 290 patients of reproductive age revealed a multifactorial origin of the aforementioned diseases. Anamnestic, gynecological, dermatoglyphic, hormonal and receptor investigation techniques used in parallel with a routine general clinical examination evidenced systemic lesions and defined clinical and pathogenetic differences in the conditions associated with hyperplasia or endometrial polyps. The authors substantiated the use of various methods in the system of treatment: the use of nonsteroidal drugs with gestagen properties and cryogenic application to the walls of the uterus.

The clinical course, hysteroscopic and histological picture of endometrial structure analysed in 150 females, aged 48-75 yrs, with endometrial fibroglandular polyps demonstrated the necessity of polyps removal only under the hysteroscopic monitoring. It was stated that in postmenopausal females who had sustained fibroglandular polypotomy the employment of hormonal therapy could hardly be a success in case of atrophic endometrial changes.