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The potassium hydrocarbonate and potassium chloride toxicity was compared in experiments on 113 albino rats. The death following introduction of maximal amounts of potassium chloride was noted to supervene earlier than it did in animals receiving equivalent doses of potassium hydrocarbonate. Simultaneous introduction of sodium hydrocarbonate lowered the toxicity of both potassium hydrocarbonate and chloride. Morphological investigations revealed that toxic doses of potassium hydrocarbonate bring about shifts in the carbohydrate and lipids metabolism. Some mechanisms behind the action produced potassium chloride and hydrocarbonate are discussed.

Experiments were carried out on dogs kept in a sealed chamber. Changes in the O2 and CO2 concentrations as well as variations of physiological functions, the so-called survival curves, were studied under the conditions of terminated O2 supply and CO2 utilization. The criteria of investigation, mathematical and physiological analysis were chosen from the point of view of predicting hazardous states during failures of the environmental control system. Tolerance limits during slow and rapid changes of the environment, phases of changes of the body state and mechanisms of a combined effect of increasing hypercapnia and hypoxia were considered.

The white rats exposed to 60 and 100 day hypokinesia showed a substantial and progressive decline in the tolerance to a maximum physical load. This was accompanied by disorders in the regulation of the oxygen balance: during load oxygen requirements were mainly met by the oxygen debt. The above changes that followed a 100 day hypokinesia returned to the normal two months later.

The toxicity of potassium hydrocarbonate and chloride was compared in tests on 113 albino rats. It was noted that following introduction of maximal amounts of potassium chloride death occurred earlier in these animals than in the ones which received equivalent doses of potassium hydrocarbonate. Simultaneous administration of sodium hydrocarbonate reduced the toxicity of potassium hydrocarbonate and potassium chloride. Morphological investigations brought out that toxic doses of potassium hydrocarbonate led to shifts of the carbohydrate and lipids metabolism. Some mechanisms underlying the action of potassium chloride and potassium hydrocarbonate are discussed.

The physiological effect of prolonged accelerations of 2 and 4 g applied longitudinally and transversely to the long axis of the body of white rats was studied. The animals exposed to accelerations for 24 hours showed a decrease in the heart rate, respiration rate, rectal temperature, pO2, and pCO2 in the peripheral tissues.