1. [The results of an experimental study of an anti-Opisthorchis preparation made from plant raw material].
- Author
-
Mefod'ev VV, Krasnov EA, Stepanova TF, and Sozonova TA
- Subjects
- Animals, Antiplatyhelmintic Agents pharmacology, Antiplatyhelmintic Agents toxicity, Cricetinae, Drug Evaluation, Preclinical, Lethal Dose 50, Male, Mesocricetus, Mice, Opisthorchiasis drug therapy, Opisthorchiasis parasitology, Opisthorchis drug effects, Plant Extracts pharmacology, Plant Extracts therapeutic use, Plant Extracts toxicity, Praziquantel analogs & derivatives, Praziquantel therapeutic use, Rats, Siberia, Time Factors, Xylenes therapeutic use, Antiplatyhelmintic Agents therapeutic use, Trees
- Abstract
Agents and biologically active fractions derived from medical plants grown in Siberia were tested in vitro and in vivo. The extract from the aspen bark displayed the highest antiopisthorchiatic activity. This agent given at a concentration of 10(-3) caused 100% death of Opisthorchis 72 hours later. In golden hamster experiments, the efficiency of the aspen bark extract was 73.48-83.0%. Butanolic and ethylacetatic extracts were found to have the greatest antiopisthorchiatic activity. The results of chemical and chromatographic studies indicated that active fractions contained salicine and its derivatives. The aspen bark extract produces no substantial toxic effect on laboratory animals and belongs to the class "Low-toxic substances".
- Published
- 1996