1. [Neurotropic action of probon compared to amidopyrine].
- Author
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Kuzina NV, Aleksandrova GM, Novikova GV, and Milogradova GP
- Subjects
- Aminopyrine therapeutic use, Analgesics therapeutic use, Animals, Brain drug effects, Diazepam antagonists & inhibitors, Diazepam pharmacology, Electroencephalography, Exploratory Behavior drug effects, Mice, Motor Activity drug effects, Orientation drug effects, Pain drug therapy, Pyrimidinones therapeutic use, Rabbits, Rats, Aminopyrine pharmacology, Analgesics pharmacology, Pyrimidinones pharmacology
- Abstract
In comparing the neurotropic action of probon and amidopyrine it became evident that both analgesics inhibit the behavioral reactions of rats in "open field" tests, fail to produce any protective action with respect to the reflex reaction of the heart in response to pain stimulation and attenuate such an effect of seduxen. By lengthening the hexobarbital-induced sleep probon and amidopyrine change the EEG nature typical of the effect produced by barbiturates. The difference between the study analgesics is rather a quantitative one, viz. in many rests probon is more potent and its action manifestes itself in a wider range of dosages.
- Published
- 1977