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1. [EXPERIMENTAL ASSESSMENT OF THE IMMUNOTROPIC EFFECTS OF ARABINOGALACTAN AND PECTINACEOUS POLYSACCHARIDES ISOLATED FROM FERULA KUCHISTANICA.]

Author

Islamova ZI, Malikova MK, Khushbaktova ZA, Rakhmanberdyeva RK, and Syrov VN

Subjects
Animals, Disease Models, Animal, Female, Male, Mice, Adjuvants, Immunologic chemistry, Adjuvants, Immunologic isolation & purification, Adjuvants, Immunologic pharmacology, Ferula chemistry, Galactans chemistry, Galactans isolation & purification, Galactans pharmacology, Immunologic Deficiency Syndromes drug therapy, Immunologic Deficiency Syndromes immunology, Pectins chemistry, Pectins isolation & purification, Pectins pharmacology, Phagocytes immunology
Abstract

It is established that arabinogalactan and pectinaceous polysaccharides isolated from Ferula kuchistanica are capable of stimulating a primary immune response in mice by increasing the number of antibody-producing cells in the spleen in response to immunization with sheep red blood cells in both intact animals (on average by 51.0%; p < 0.005) and those with secondary immunodeficiency caused by irradiation (on average by 164.4%; p < 0.005). The treatment with compounds studied also significantly increased the functional condition of cells of the mononuclear phagocyte system (on average by 27.0%; p < 0.005).

Published
2016

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