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Introduction: Diabetes mellitus characterized by high glycemic levels is routinely associated with many mineral abnormalities. The purpose of this study was to evaluate the levels of serum magnesium among subjects with diabetes mellitus and to compare and analyze the same in normal non diabetics. Materials and Methods: In this case control study conducted at Malla Reddy Hospital, 50 subjects known to be diabetics were considered as cases and 50 apparently normal non- diabetics were the controls. Serum magnesium was estimated, compared and analyzed. Results: Serum magnesium levels were 1.89 ± 0.32 among cases and 2.26 ± 0.27 among controls. Extreme statistical significance was observed between both the groups. Conclusion: Serum magnesium levels were found to be decreased in subjects with diabetes mellitus. We conclude that diabetes mellitus could influence magnesium homeostasis. Keywords: Diabetes mellitus, Magnesium, Fasting plasma glucose.

Background: Thyroid hormones are a potent regulator of metabolism, playing a crucial role in regulating energy expenditure and in key physiological mechanisms. Their prominent and well-known role is an increase in basal energy expenditure obtained by acting on carbohydrate, protein and lipid-metabolism. Hypothyroidism is relatively common and is associated with an unfavorable effect on lipid metabolism. Few studies reveal subclinical hypothyroidism to be a risk factor for increased incidence of lipid abnormalities and resulting in cardiovascular abnormalities. Aim: Hence study was taken up to find the association of serum lipids with subclinical hypothyroidism. Methodology: This was a retrospective study conducted in the department of Biochemistry, Malla Reddy hospital. Biochemically identified 102 subjects of Subclinical hypothyroidism subjects between 15-50 years and evaluated for lipid profile were included in the study. In our study, the mean serum total cholesterol, triglycerides, HDL cholesterol and LDL cholesterol expressed in mg/dl were 189.9824.16, 166.48+17.4, 37.62+2.89 and 121.34+27.31mg/dl respectively. 41 subjects out of 102 had higher total cholesterol, triglycerides and LDL cholesterol with lesser HDL cholesterol from the acceptable limits. Conclusion: We conclude that impaired lipid parameters are associated with subclinical hypothyroidism. Hence a regular screening for lipid profile should be considered in subclinical hypothyroidism for early diagnosis, prevention and management of cardiovascular complications. Keywords: TSH, HDL cholesterol, LDL cholesterol, Sub clinical hypothyroidism.