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Pleomorphic adenomas are the most common salivary gland tumours. It is rare to find these tumours in the submandibular glands. This case report is about a twenty-year old male patient who presented with huge mass on the submandibular region. The facial disfigurement due to the tumour was responsible for low self-esteem in this young male. The patient was treated with complete left submandibular gland excision.

Primary fungal epiglotitis is the isolated fungal infection of the epiglottis, without affecting the other body parts such as the larynx, lungs, pharynx, and oral cavity. It is an extremely rare clinical entity. Very few cases could be found in world literature. Pain throat and/or odynophagia are common clinical presentations. It can be secondary to inhaled steroid therapy which is usually mild.: In this article, we introduced a rare case of fungal epiglotitis in a 66 years old immunocompetent male presented with odynophagia without any other symptom or sign. In endoscopic laryngoscopy, using a 70 scope, a white lesion on swollen epiglottis was seen and rest of larynx was normal. No cervical lymphadenopathy was seen. Laryngeal area was tender on deep palpation. Patient was put on antibiotics and anti-inflammatory agents. There was no response even after 24 hers of starting treatment. Patient was put on empirically oral antifungal treatment and he improved in 6-8 hrs. Diagnosis of fungal epiglotitis was clinical, based on patient’s history, signs and sypmtoms. Signs included the inflammatory changes of the epiglotis and candida whitish discoloration of it. There was rapid and obvious improvement in condition of the patient, once started on oral antifungal treatment.

Parotid infection/abscess leading to facial nerve palsy is a rare presentation. Normally, malignant parotid masses are associated with facial nerve palsy. We present a case of parotitis which was complicated by facial nerve dysfunction and recovered well with conservative treatment.

Cancer is the most threatening disorder with increasing stuffers globally. Immune system of human body carries a set of defensive processes whenever cancer is detected by its specialized cells. While immunosurveillance, the host fight against foreign antigens. By targeting surface antigens expressed in tumor cells, monoclonal antibodies have demonstrated efficacy as cancer therapeutics. The checkpoint blockade therapy involves the use of antibodies to block pathways inhibiting the endogenous immune response to cancer. Adoptive cell transfer (ACT) is highly personalized cancer bearing host of immune cells with direct anticancer activity. We emphasize how the history of cancer immunotherapy paved the path for discoveries that are now standard of care in this review article.

Haemangioma is a benign vascular soft tissue tumor which is compressible and nonpulsatile mass it may be non-blanching at times (as in the present case). Such benign vascular lesions frequently occur in the head and neck, approximately 80% are found in these areas. But they are very rare to be found on pinna. In our case, it was excised surgically on histolopathological examination only the diagnosis was made.