1. Association of Brain Volume and Retinal Thickness in the Early Stages of Alzheimer’s Disease
- Author
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Sunu, Mathew, Darrell, WuDunn, Devin D, Mackay, Aaron, Vosmeier, Eileen F, Tallman, Rachael, Deardorff, Alon, Harris, Martin R, Farlow, Jared R, Brosch, Sujuan, Gao, Liana G, Apostolova, Andrew J, Saykin, and Shannon L, Risacher
- Subjects
Psychiatry and Mental health ,Clinical Psychology ,General Neuroscience ,General Medicine ,Geriatrics and Gerontology - Abstract
Background: The eye has been considered a ‘window to the brain,’ and several neurological diseases including neurodegenerative conditions like Alzheimer’s disease (AD) also show changes in the retina. Objective: To investigate retinal nerve fiber layer (RNFL) thickness and its association with brain volume via magnetic resonance imaging (MRI) in older adults with subjective or objective cognitive decline. Methods: 75 participants underwent ophthalmological and neurological evaluation including optical coherence tomography and MRI (28 cognitively normal subjects, 26 with subjective cognitive decline, 17 patients diagnosed with mild cognitive impairment, and 4 with AD). Differences in demographics, thickness of RNFL, and brain volume were assessed using ANCOVA, while partial Pearson correlations, covaried for age and sex, were used to compare thickness of the peripapillary RNFL with brain volumes, with p
- Published
- 2023